Table 3

Renal, intraglomerular, and systemic hemodynamic function and vascular parameter response to FBX treatment in HCs and patients with T1D studied under euglycemic and hyperglycemic clamp conditions

ParameterHC (n = 24)T1D (n = 49)
EuglycemiaHyperglycemia
BaselineFBXP valueBaselineFBXP valueBaselineFBXP value
Renal hemodynamic function
 ERPF (mL/min/1.73 m2)654 ± 111639 ± 910.3818647 ± 131657 ± 1130.5329676 ± 133665 ± 1240.4235
 GFR (mL/min/1.73 m2)117 ± 17119 ± 150.2836115 ± 19113 ± 160.1893130 ± 21133 ± 190.2142
 FF0.18 ± 0.040.19 ± 0.030.31240.18 ± 0.040.17 ± 0.030.10190.20 ± 0.040.21 ± 0.050.1064
 RBF (mL/min/1.73 m2)1,058 ± 2021,035 ± 1780.40441,051 ± 2191,063 ± 1850.63001,071 ± 2091,052 ± 2030.3956
 RVR (mmHg/L/min)0.077 ± 0.0150.077 ± 0.0150.68960.081 ± 0.0220.077 ± 0.0140.13270.080 ± 0.0160.082 ± 0.0200.4171
Intraglomerular hemodynamic parameters
 PGLO (mmHg)48.9 ± 2.749.4 ± 2.50.227554.4 ± 4.153.4 ± 3.20.049754.9 ± 4.056.1 ± 4.10.0664
 RA (dyne ⋅ s ⋅ cm−5)2,246 ± 6402,208 ± 7040.68452,167 ± 8852,010 ± 6620.19052,170 ± 7212,132 ± 8150.7373
 RE (dyne ⋅ s ⋅ cm−5)994 ± 2631,028 ± 1970.39311,690 ± 4241,604 ± 3310.12991,871 ± 4231,997 ± 5730.0829
 RA/RE ratio2.39 ± 0.862.20 ± 0.760.15041.31 ± 0.521.29 ± 0.470.66411.21 ± 0.441.11 ± 0.430.1667
Systemic hemodynamic function
 HR (bpm)62 ± 861 ± 90.404267 ± 1166 ± 100.860564 ± 1164 ± 120.7484
 SBP (mmHg)107 ± 9106 ± 80.3267112 ± 10109 ± 90.0491113 ± 9112 ± 90.4405
 DBP (mmHg)64 ± 664 ± 70.610667 ± 666 ± 70.282369 ± 769 ± 70.6546
Vascular parameters
 Aortic AIX (%)−7.7 ± 9.7−9.6 ± 8.10.4353−3.0 ± 11.5−4.1 ± 11.80.4247−1.8 ± 14.3−1.5 ± 12.50.8605
 Carotid AIX (%)−3.6 ± 13.6−4.3 ± 14.10.75290.5 ± 15.01.6 ± 14.70.47404.4 ± 15.72.5 ± 14.90.1723
 Carotid radial PWV (m/s)7.1 ± 1.06.8 ± 1.10.23407.3 ± 1.17.2 ± 1.10.70437.6 ± 1.07.3 ± 1.30.0728
 Carotid femoral PWV (m/s)5.5 ± 1.15.3 ± 1.00.53325.8 ± 1.05.6 ± 1.20.29795.8 ± 0.95.6 ± 1.10.0972
 FMD (%)4.2 ± 3.15.0 ± 3.40.24284.1 ± 4.45.3 ± 3.40.82514.2 ± 4.14.8 ± 3.60.1733
 FMD/flow0.047 ± 0.0380.073 ± 0.0760.16160.051 ± 0.0560.050 ± 0.0480.93430.056 ± 0.0410.061 ± 0.0500.5058
 GMD (%)15.5 ± 6.015.9 ± 4.70.662911.9 ± 5.111.1 ± 6.30.277713.0 ± 5.712.6 ± 5.20.3596
HR variability
 RMSSD (ms)64.1 ± 29.180.9 ± 46.90.029363.5 ± 42.663.6 ± 43.80.979667.8 ± 44.266.5 ± 47.30.7555
 SDNN (ms)77.4 ± 22.888.2 ± 37.80.076976.2 ± 33.978.9 ± 36.90.457979.0 ± 35.977.4 ± 39.00.6982
  • Values are reported as the mean ± SD, unless otherwise indicated. n, number of participants.