Table 2

Variants associated with lower 24-h EE, lower RMR, and higher maximum BMI in American Indians

Chr.PositionVariant IDGene(s)R/NR alleleRAF24-h EE (n = 419)RMR (n = 509)Maximum BMI (n = 5,870)
β (SE)Pβ (SE)Pβ (SE)P
1025735858rs11014566GPR158G/A0.60−33.0 (10.5)1.7 × 10−3−31.1 (12.1)9.9 × 10−30.017 (0.005)4.7 × 10−4
2130662480LINC00189, BACH1—/AAG0.30−30.6 (11.1)6.0 × 10−3−34.5 (13.3)9.4 × 10−30.014 (0.005)3.9 × 10−3
1297806525rs12424131NEDD1, RMSTA/G0.88−42.8 (15.5)5.6 × 10−3−55.8 (19.2)3.6 × 10−30.018 (0.007)9.9 × 10−3
1297810465rs17026922NEDD1, RMSTG/A0.92−46.8 (17.8)8.5 × 10−3−65.7 (22.6)3.6 × 10−30.020 (0.008)1.2 × 10−2
1421113898rs56069351OR6S1, ANGT/C0.25−33.0 (11.7)4.9 × 10−3−42.1 (14.1)2.7 × 10−30.012 (0.005)1.5 × 10−2
204157857rs1538072SMOXG/C0.77−35.9 (12.7)4.6 × 10−3−52.1 (15.0)5.4 × 10−40.012 (0.006)3.4 × 10−2
377645020rs80275771ROBO2A/T0.16−38.8 (14.8)8.9 × 10−3−45.9 (16.9)6.7 × 10−30.014 (0.007)3.9 × 10−2
  • Variant position is based on human genome Build 37. Variant identification number (rs no.) is based on dbSNP version 141. Risk (R) allele is defined as the allele associated with lower 24-h EE, lower RMR, and higher maximum BMI. RAF was calculated in full-heritage Pima Indians. β-Coefficient (β) is expressed per copy of the risk allele in kcal/day (24-h EE and RMR) and loge (BMI) units. Results are adjusted for age, sex, FM and FFM (only for 24-h EE and RMR analyses), SPA (only for 24-h EE), birth year (only for BMI analysis), and the first five genetic principal components in a mixed model that accounted for genetic relationships among individuals. Variants are sorted by their P value for the association with maximum BMI. Chr., chromosome; NR, nonrisk.