Table 3

Correlation analyses of two identified bacteria with MBH/amygdala signal ratio (L) and nutritional parameters

Parasutterella sp.: phylum ProteobacteriaMarinilabiliaceae (unclass.): phylum Bacteroidetes
ρPρP
MBH/amygdala (L)−0.3830.0073*−0.2990.0398*
Fats−0.2980.0439*−0.1870.2132
Carbohydrates−0.0750.6194−0.1320.3801
Proteins−0.2830.0567−0.1010.5047
Total energy−0.1960.1908−0.1660.2724
  • Parasutterella sp. correlates negatively with HI and fat intake, while Marinilabiliaceae correlates with HI but not with nutritional parameters. Correlation analyses were performed within the obese subject group (MBH/amygdala signal ratio [L]: n = 48 subjects, nutrition: n = 45 subjects) using the Spearman rank correlation test. In our exploratory approach of the microbiota, we investigated the correlation of 26 bacteria with HI in order to detect the bacteria with the largest effect sizes (at a nominal significance level of 0.05). In that analysis, the findings were not robust to multiple testing by Bonferroni correction when we used the 26 species as independent cases. However, gut bacteria are not independent from each other, and co-occurrence analysis revealed that the core measurable microbiome in relation to HI can be subdivided into 3 major clusters. Within the clusters, Parasutterella sp. but not Marinilabiliaceae holds against multiple testing. unclass., unclassified. *Significant P value (P < 0.05).