Table 1

General and metabolic variables, albuminuria, creatinine clearance, plasma creatinine, and cystatin C in control and diabetic SM22+Nox5 and SM22+Nox5+ mice (n = 10–20/group)

SM22+Nox5SM22+Nox5+
ControlDiabetesControlDiabetes
Body weight (g)32 ± 0.928 ± 0.6*32 ± 0.726 ± 0.6^
Kidney weight/body weight (%)0.64 ± 0.020.99 ± 0.03*0.68 ± 0.021.12 ± 0.03^#
Plasma glucose (mmol/L)11.9 ± 0.533.0 ± 2.4*12.0 ± 0.834.2 ± 1.4^
Glycated hemoglobin (%)4.3 ± 0.111.4 ± 0.5*4.2 ± 0.111.2 ± 0.5^
Systolic BP (mmHg)105 ± 0.9109 ± 1.0108 ± 0.9110 ± 1.2
Food intake (g)2.9 ± 0.25.8 ± 0.5*3.1 ± 0.36.4 ± 0.3^
Water intake (mL)2.85 ± 0.4027.5 ± 2.0*3.0 ± 0.426.9 ± 1.6^
Urine output (mL)0.56 ± 0.0822.7 ± 1.8*0.57 ± 0.1024.4 ± 1.61^
Creatinine clearance (mL/min/m2)6.8 ± 0.519.8 ± 2.6*6.9 ± 1.113.9 ± 2.7^
Albuminuria (µg/24 h)38 ± 4.5651 ± 80*27 ± 2.6864 ± 70^
ACR (µg/mg)124 ± 211,130 ± 147*97 ± 111,648 ± 203^††
Plasma creatinine (µmol/L)22.7 ± 2.317.7 ± 2.529.6 ± 3.221.5 ± 4.7
Cystatin C (ng/mL)346 ± 24208 ± 32*431 ± 28134 ± 18*
  • Data are shown as mean ± SEM. BP, blood pressure.

  • *P < 0.05 vs. control SM22+Nox5 mice;

  • ^P < 0.05 vs. control SM22+Nox5+ mice;

  • P = 0.059 and

  • ††P = 0.057 vs. diabetic SM22+Nox5 mice;

  • #P < 0.05 vs. diabetic SM22+Nox5 mice.