Table 2

Interactions of physical activity, MVPA, and sedentary behavior with the overall GRS and effects on BMI, body composition measures, and waist circumference

Continuous*Tertiles
β for interaction (SE)P value123
BMI, kg/m2
 Total physical activity
  Model 1−0.12 (0.04)0.0050.82 (0.10)0.72 (0.10)0.43 (0.09)
 MVPA
  Model 1−0.06 (0.02)0.0050.78 (0.10)0.75 (0.10)0.39 (0.09)
  Model 2−0.04 (0.02)0.110.74 (0.11)0.75 (0.10)0.41 (0.10)
 Sedentary time
  Model 10.09 (0.03)0.0060.44 (0.09)0.81 (0.10)0.73 (0.10)
  Model 20.06 (0.04)0.100.46 (0.10)0.77 (0.10)0.69 (0.11)
Fat mass, kg
 Total physical activity
  Model 1−0.26 (0.09)0.0031.58 (0.20)1.37 (0.20)0.73 (0.18)
 MVPA
  Model 1−0.13 (0.04)0.0011.48 (0.20)1.48 (0.20)0.65 (0.17)
  Model 2−0.09 (0.05)0.061.36 (0.22)1.48 (0.20)0.76 (0.20)
 Sedentary time
  Model 10.20 (0.06)0.0020.70 (0.18)1.60 (0.20)1.41 (0.20)
  Model 20.13 (0.07)0.080.73 (0.20)1.52 (0.19)1.34 (0.23)
Fat mass index, kg/m2
 Total physical activity
  Model 1−0.10 (0.03)0.0020.60 (0.07)0.52 (0.07)0.27 (0.06)
 MVPA
  Model 1−0.05 (0.02)0.0010.56 (0.07)0.56 (0.07)0.24 (0.06)
  Model 2−0.04 (0.02)0.030.53 (0.08)0.56 (0.07)0.27 (0.07)
 Sedentary time
  Model 10.07 (0.02)0.0040.27 (0.07)0.61 (0.07)0.51 (0.07)
  Model 20.04 (0.03)0.140.29 (0.07)0.58 (0.07)0.48 (0.08)
Fat percentage, %
 Total physical activity
  Model 1−0.13 (0.06)0.0230.94 (0.12)0.85 (0.13)0.49 (0.12)
 MVPA
  Model 1−0.07 (0.03)0.0120.84 (0.12)0.99 (0.13)0.41 (0.13)
  Model 2−0.04 (0.03)0.200.77 (0.14)0.99 (0.13)0.50 (0.14)
 Sedentary time
  Model 10.11 (0.04)0.0070.43 (0.12)0.99 (0.13)0.86 (0.13)
  Model 20.09 (0.05)0.080.45 (0.14)0.94 (0.13)0.86 (0.15)
Fat-free mass, kg
 Total physical activity
  Model 1−0.05 (0.05)0.2910.67 (0.11)0.50 (0.11)0.49 (0.10)
 MVPA
  Model 1−0.02 (0.02)0.4330.66 (0.11)0.51 (0.11)0.45 (0.11)
  Model 20.00 (0.03)0.9710.58 (0.12)0.51 (0.11)0.44 (0.12)
 Sedentary time
  Model 10.06 (0.04)0.1170.50 (0.10)0.53 (0.11)0.67 (0.11)
  Model 20.06 (0.04)0.1610.49 (0.11)0.50 (0.11)0.64 (0.13)
Waist circumference, cm
 Total physical activity
  Model 1−0.28 (0.10)0.0061.70 (0.23)1.59 (0.23)0.85 (0.21)
 MVPA
  Model 1−1.15 (0.47)0.0141.60 (0.22)1.67 (0.23)0.80 (0.21)
  Model 2−0.05 (0.05)0.331.57 (0.25)1.67 (0.23)0.93 (0.24)
 Sedentary time
  Model 10.40 (0.13)0.0010.76 (0.21)1.82 (0.22)1.54 (0.23)
  Model 20.21 (0.09)0.020.79 (0.24)1.75 (0.22)1.53 (0.26)
  • Model 1 and model 2 are adjusted for the log of sampling weight, field center, age, sex, five principal components for population structure, education, income, employment, smoking, alcohol use, energy intake, and AHEI as fixed effects, and genetic relatedness, household, and block groups as random effects. Model 2 was simultaneously tested for MVPA × GRS and sedentary behavior × GRS interactions.

  • *Data are interaction effect sizes per 1-SD (six-unit) increment of GRS × 100 counts/min increment of total physical activity, per 1-SD increment of GRS × 10-min increment of MVPA, and per 1-SD increment of GRS × 1-h increment of sedentary time.

  • †Data are effect sizes per 1-SD increment of GRS according to tertiles of total physical activity, MVPA, and sedentary time.