Table 2

Association between 25(OH)D concentration and vitamin D sufficiency and IA in the TEDDY nested case-control study

Vitamin D measureAll case subjects (n = 376) and control subjects (n = 1,041)Case subjects with multiple autoantibodies (n = 230) and control subjects (n = 639)
Childhood 25(OH)D concentration (per 5 nmol/L increase)0.93 (0.89–0.97)0.91 (0.87–0.96)
Early infancy 25(OH)D concentration (per 5 nmol/L increase)0.94 (0.91–0.98)0.93 (0.89–0.97)
Childhood vitamin D sufficiency (≥50 vs. <50 nmol/L)0.68 (0.52–0.89)0.61 (0.43–0.86)
Early infancy vitamin D sufficiency (≥50 vs. <50 nmol/L)0.59 (0.44–0.79)0.57 (0.40–0.83)
  • Data are OR (95% CI). Separate conditional logistic regression models were run for each vitamin D variable, adjusting for HLA-DR3/4 status and the first two PCs indicating ancestry. For the early infancy vitamin D measures, we also adjusted for age and season of sample collection at the first visit.

  • †Average of all visits prior to and including the seroconversion visit.

  • ‡Defined by the first 25(OH)D measure occurring before 12 months of age in 360 case subjects and their 981 control subjects. There were 220 case subjects with multiple autoantibodies, with their 603 control subjects, with a measure before 12 months of age.