Table 1

Heritability of metabolic phenotypes

	n	h² (SE)	LRT P value	Fixed-effect covariates
				P value
				Age	Sex	OSA
HbA_1c	46	0.35 (0.33)	0.146	0.0114	ns	ns
Fasting values
Glucose	46	0	0.5	ns	ns	ns
Insulin	48	0.60 (0.25)⁺	0.015	ns	ns	ns
C-peptide	48	0.90 (0.15)⁺	0.0001^§	0.0004	ns	ns
ISR	42	0.79 (0.33)⁺	0.02	ns	ns	ns
HOMA-IR	48	0.67 (0.26)	0.0125	0.007	ns	ns
HOMA-β	48	0.30 (0.30)	0.165	ns	ns	ns
QUICKI	48	0.67 (0.26)	0.013	0.040	ns	ns
Postchallenge values
Matsuda index	48	0	0.5	ns	ns	ns
Insulinogenic index	46	0	0.5	0.041	ns	ns
AUC glucose	46	0	0.5	0.0003
AUC insulin	46	0	0.5	ns	ns	ns
IncrAUC glucose	46	0	0.5	0.0002	ns	ns
IncrAUC insulin	46	0	0.5	ns	ns	ns
IncrAUC insulin/IncrAUC glucose	46	0	0.5	0.038	ns	ns

SEs are shown in parentheses alongside all heritability estimates greater than zero. LRT P value: P values from LRT indicating whether the heritability estimated is significantly different from zero. Fixed-effect covariates P value: reported P values from LRT indicating whether the variable significantly impacted the heritability model. Age and sex were retained in the model regardless of their LRT P value, while BMI and OSA were dropped if P > 0.1 (reported in table as not significant [ns]) to result in a parsimonious model. Statistically significant data appear in boldface type. AUC, area under the curve; IncrAUC, incremental area under the curve.
§P values exceeding the Bonferroni corrected threshold for significance of P = 0.004 (corrected for the number of traits analyzed).
+BMI was a significant covariate and estimate was adjusted for BMI.