Table 1

Overview on the sequence of PET examinations and the injected amounts of AZ12204657 (dose escalation) or AZ8154 (preadministration) in each animal

PET 1PET 2PET 3
TypeCompoundDoseTypeCompoundDoseTypeCompoundDose
Pig 1BaselineAZ12204657<1 µgPreadministrationAZ81545 mg/kg
Pig 2BaselineAZ122046570.24 µgPreadministrationAZ81545 mg/kg
Pig 3BaselineAZ122046570.15 µgDose-escalationAZ122046575.3 µgDose-escalationAZ1220465770 µg
Pig 4BaselineAZ122046570.52 µgDose-escalationAZ122046573.4 µgDose-escalationAZ1220465718.5 µg
Pig 5BaselineAZ122046570.74 µgBaselineAZ122046570.43 µgPreadministrationAZ81545 mg/kg