Table 1

Key experimental findings and the models that can replicate them

Models with Ca2+-driven oscillationsModels with metabolism-driven oscillations
Fast bursting and Ca2+ patternsCK83, KM89, SK92, D98, F03, BS04, C11, Dd06DOM, IOM
Slow bursting and Ca2+ patternsD98, BS04, C11, Dd06T97, DOM, IOM
Compound bursting and Ca2+ patternsB08DOM, IOM
Subthreshold oscillationsNoneT97, DOM, IOM
Metabolic oscillations with Ca2+ clamped by DzNoneDOM, IOM
Oscillations in KATP conductance measured with voltage ramps during islet burstingNoneT97, DOM, IOM
Ca2+ oscillations stimulated by KICCK83, KM89, SK92, D98, F03, BS04, C11, Dd06IOM
Sawtooth oscillations in PercevalCK83, KM89, SK92, D98, F03, BS04, C11, Dd06IOM
Sawtooth oscillations in PKARNoneIOM
  • B08, Bertram et al., 2008 (48); BS04, Bertram and Sherman, 2004 (49); C11, Cha et al., 2011 (17); CK83, Chay and Keizer, 1983 (10); D98, Detimary et al., 1998 (15); Dd06, Diederichs, 2006 (50); DOM, Bertram et al., 2007 (27); F03, Fridlyand et al., 2003 (16); IOM, McKenna et al., 2016 (23); KM89, Keizer and Magnus, 1989 (40); SK92, Smolen and Keizer, 1992 (13); T97, Tornheim, 1997 (20).