Table 1

Adolescent and young-adult pancreata contain a population of highly proliferative α-related cells that are mostly glucagon negative: a summary of markers found to be detected or absent in α-, highly proliferative α-related cell, β-, γ-, δ-, and ε-cells

α-CellHighly proliferative α-related cellβ-Cellγ-Cellδ-Cellε-Cell
DetectedGlucagonARXInsulinPPSSGhrelin
GLP1Sox9CytNkx6.1
ARXNkx2.2MafA
Sox9CytInsm1GAD65
Nkx2.2Isl1 and -2Insm1
Insm1SynaptophysinIsl1 and -2
Isl1 and -2CgANkx2.2
SynaptophysinSCG3Synaptophysin
SCG3SNAP25CgA
SNAP25SYT1SCG3
SYT1Ki67SNAP25
CgAPCNASYT1
Ki67pHH3
AbsentInsulinGlucagonGlucagonKi67Ki67Ki67
Nkx6.1GLP1
MafAInsulinARX
GAD65Nkx6.1Sox9Cyt
MafAKi67
GAD65
Pdx1
SCG3