Adolescent and young-adult pancreata contain a population of highly proliferative α-related cells that are mostly glucagon negative: a summary of markers found to be detected or absent in α-, highly proliferative α-related cell, β-, γ-, δ-, and ε-cells
| α-Cell | Highly proliferative α-related cell | β-Cell | γ-Cell | δ-Cell | ε-Cell | |
|---|---|---|---|---|---|---|
| Detected | Glucagon | ARX | Insulin | PP | SS | Ghrelin |
| GLP1 | Sox9Cyt | Nkx6.1 | ||||
| ARX | Nkx2.2 | MafA | ||||
| Sox9Cyt | Insm1 | GAD65 | ||||
| Nkx2.2 | Isl1 and -2 | Insm1 | ||||
| Insm1 | Synaptophysin | Isl1 and -2 | ||||
| Isl1 and -2 | CgA | Nkx2.2 | ||||
| Synaptophysin | SCG3 | Synaptophysin | ||||
| SCG3 | SNAP25 | CgA | ||||
| SNAP25 | SYT1 | SCG3 | ||||
| SYT1 | Ki67 | SNAP25 | ||||
| CgA | PCNA | SYT1 | ||||
| Ki67 | pHH3 | |||||
| Absent | Insulin | Glucagon | Glucagon | Ki67 | Ki67 | Ki67 |
| Nkx6.1 | GLP1 | |||||
| MafA | Insulin | ARX | ||||
| GAD65 | Nkx6.1 | Sox9Cyt | ||||
| MafA | Ki67 | |||||
| GAD65 | ||||||
| Pdx1 | ||||||
| SCG3 |