Table 2

Comparison of investigations before and after pioglitazone treatment

InvestigationBefore treatmentAt 12-month treatmentAt 24-month treatmentReference range
Weight (kg) diabetes profile49.048.650.5
HBA1c (mmol/mol)61423120–40
Glucose (mmol/L)12.04.03.7<6.1
Insulin (pmol/L)405NDND10–60
Liver enzymes
 ALT (IU/L)643533<30
 GGT (IU/L)341615<35
Hormonal profile
 Free testosterone (pmol/L)19884ND<50
 SHBG (nmol/L)1614ND20–90
 Free androgen index450214ND<80
 FSH (IU/L)8.84.57.13–25
 LH (IU/L)14.84.35.12.0–25
Lipid profile
 TG (mmol/L)13.22.41.6<1.7
 HDL (mmol/L)0.40.60.7>1.0
 Total cholesterol (mmol/L)4.733.8<5.1
 LDL (mmol/L)21.32.4<3.4
  • ALT, alanine aminotransferase; FSH, follicle-stimulating hormone; GGT, γ-glutamyl transferase; LH, luteinizing hormone; ND, not done; SHBG, sex hormone–binding globulin; TG, triglyceride.