Table 3

Instrumental variable estimates for the weighted genetic score and single AHSG SNPs reflecting the association of a 50 μg/mL increase in fetuin-A concentration with diabetes risk

Weighted genetic scorers4917rs2070633rs2248690
EPIC-InterAct*1.02 (0.97, 1.07)1.02 (0.98, 1.07)1.01 (0.95, 1.08)1.04 (0.96, 1.10)
EPIC-InterAct and DIAGRAM combined1.02 (1.00, 1.06)1.01 (0.98, 1.05)1.04 (1.00, 1.08)
  • Data are HRs (for EPIC-InterAct) or ORs (for EPIC-InterAct and DIAGRAM combined) and 95% CIs per 50 μg/mL increase in fetuin-A concentration. Instrumental variable estimates were obtained from two-stage least squares procedure. Estimates for EPIC-InterAct and DIAGRAM have been combined with a fixed-effects meta-analysis.

  • *EPIC-InterAct: n = 22,379 including 12,975 incident case subjects with type 2 diabetes.

  • †DIAGRAM: n = 69,033 including 12,171 incident case subjects with type 2 diabetes.