Table 2

Five loci were associated (P ≤ 5 × 10−8) with CKD, microalbuminuria, and eGFR phenotypes in T2D or T1D+T2D subjects

CHR:BPPhenotypeSNP (locus)DiscoveryReplicationJoint analysis
EA/NEA (Info), EAFOR/β (95% CI)PAncestryOR/β (95% CI)POR/β (95% CI)PN
20: 9351150T2D CKDrs2206136 (PLCB4)A/T (0.98), 0.42OR 1.20 (1.08, 1.34)2.1 × 10−8EuropeanOR 1.02 (0.91, 1.15)0.69OR 1.13 (1.05, 1.21)9.0 × 10−511,900
Asian and EuropeanOR 1.03 (0.94, 1.13)0.68OR 1.12 (1.05, 1.19)2.1 × 10−413,813
6: 89948232T2D microalbu-minuriars9942471 (GABRR1)A/C (0.99), 0.64OR 1.24 (1.15, 1.34)2.1 × 10−7EuropeanOR 1.32 (0.99, 1.75)0.06OR 1.25 (1.16, 1.34)4.5 × 10−84,801
Asian and EuropeanOR 1.11 (0.99, 1.23)0.12OR 1.15 (1.08, 1.23)1.2 × 10−55,559
16: 20400839T2D eGFRrs11864909 (UMOD)T/C (1.00), 0.28β 2.42 (1.28, 3.56)2.7 × 10−5Europeanβ 2.22 (1.16, 3.28)4.1 × 10−5β 2.31 (1.54, 3.09)4.6 × 10−912,343
Asian and Europeanβ 2.30 (1.48, 3.12)3.6 × 10−8β 2.34 (1.68, 3.00)4.4 × 10−1219,747
2: 170646916T1D+T2D eGFRrs1974990* (SSB)G/T (0.98), 0.08β 4.07 (2.61, 5.52)4.8 × 10−8EuropeanNo replication availableβ 4.07 (2.61, 5.52)4.8 × 10−813,158
Asian and Europeanβ 0.04 (−2.69, 2.76)0.98β 3.17 (1.88, 4.45)1.4 × 10−614,828
7: 151415041T1D+T2D eGFRrs10224002 (PRKAG2)A/G (0.92), 0.74β 1.75 (0.85, 2.66)1.5 × 10−4Europeanβ 2.15 (0.93, 3.37)5.8 × 10−4β 1.89 (1.17, 2.62)3.4 × 10−720,495
Asian and Europeanβ 2.42 (1.28, 3.56)3.2 × 10−5β 2.01 (1.30, 2.72)2.7 × 10−822,165
16: 20400839T1D+T2D eGFRrs11864909 (UMOD)T/C (0.99), 0.29β 1.90 (1.05, 2.74)1.1 × 10−5Europeanβ 2.22 (1.16, 3.28)4.1 × 10−5β 2.02 (1.36, 2.69)2.1 × 10−916,304
Asian and Europeanβ 2.30 (1.48, 3.12)3.6 × 10−8β 2.11 (1.52, 2.70)2.3 × 10−1223,708
  • BP, base pair; CHR, chromosome; EA, effect allele; EAF, effect allele frequency; NEA, non-effect allele.

  • *rs1974490 was only available in the 1000G reference panel and was not imputed in the European studies used in the replications.