Table 4

Significance of associations between HbA1c known genetic determinants and fructosamine and percent glycated albumin in ARIC

SNPChr:positionClosest geneA1/A2WhitesBlacks
A1 freqP value fructosamineP value glycated albuminP value HbA1cA1 freqP value fructosamineP value glycated albuminP value HbA1c
rs104689617:80685533FN3KRPT/C0.310.0340.0480.0520.240.6610.4550.585
rs1077462512:111910219ATXN2G/A0.480.5710.0320.0080.090.2210.1420.503
rs1082334310:71091013HK1G/A0.260.4520.0651.1E-060.450.8080.5290.899
rs1083096311:92708710MTNR1BG/C0.280.0010.0030.0060.070.1340.0350.222
rs1124891416:293562ITFG3C/T0.350.0110.2290.0550.360.0670.3540.485
rs115584718:118185733SLC30A8G/A0.320.0058.2E-050.0100.090.3090.1760.989
rs1160333411:72432985ARAP1A/G0.160.0050.0780.2280.060.7880.9500.734
rs117080673:123065778ADCY5G/A0.230.0700.0010.0340.160.0020.0030.074
rs119546495:157055491SOX30G/C0.00NANANA0.050.8120.2200.184
rs119641786:109562035C6orf183G/A0.430.8610.8440.7020.360.1800.7480.475
rs126218442:48414735FOXN2C/T0.390.7320.2940.3580.840.8290.8530.666
rs1281912412:48409054RP1A/C0.470.7650.9300.0010.210.5000.8260.146
rs131343274:144659795FREM3A/G0.320.8000.6620.0310.300.2200.8540.772
rs14028372:169757354G6PC2T/C0.220.0169.3E-052.7E-070.310.4710.7280.656
rs155890216:53803574FTOA/T0.410.5450.0170.1310.110.0650.1760.514
rs175090012:24021231ATAD2BC/T0.140.3090.1520.0270.090.6040.5240.802
rs1753390319:17256523MYO9BA/G0.210.5770.1675.0E-040.240.4030.2320.689
rs1774732410:114752503TCF7L2C/T0.231.7E-043.2E-051.8E-040.070.3960.7550.890
rs18005626:26093141HFEA/G0.060.3370.1280.0010.010.8460.6700.146
rs1988466:26107463HFEA/G0.160.3900.1980.1230.880.5330.2700.260
rs211007312:7075882PHB2T/C0.100.3210.9380.0020.420.1770.3490.160
rs23832089:22132076MTAPG/A0.180.0080.0190.0070.190.2930.7630.596
rs240895512:48499131SENP1G/T0.480.5670.8790.0020.630.8130.8240.632
rs2677381:150940625CERS2G/T0.210.4440.4340.5110.040.8530.7450.297
rs27791161:158585415SPTA1T/C0.270.7140.7929.9E-060.220.1110.1670.961
rs28258713:113351662ATP11AG/A0.120.5860.2481.0E-040.690.0500.1420.246
rs38240657:44247258GCKT/C0.423.3E-040.0020.1250.240.0860.1340.910
rs46075177:44235668GCKA/G0.172.0E-040.0035.7E-050.110.0880.0970.244
rs47370098:41630405ANK1A/G0.240.1260.5150.0180.460.2740.4610.361
rs474598210:71089843HK1G/T0.070.1900.2635.8E-060.100.8890.9210.602
rs482026822:37469591TMPRSS6G/A0.460.2640.3500.0100.720.0730.0290.181
rs5608872:169763148G6PC2T/C0.300.0800.0030.0030.950.8110.5830.861
rs5794599:136154168ABOC/T0.230.2680.3400.0010.130.2100.4870.600
rs5924236:139840693CITED2A/C0.460.5140.5350.0630.610.3230.6050.333
rs64743598:41549194ANK1C/T0.030.9790.4864.3E-040.270.0770.0470.879
rs69805078:42383084SLC20A2A/G0.390.2560.8730.0150.480.5140.5570.663
rs70404099:91503236C9orf47G/C0.070.4990.7650.0010.260.0280.0050.115
rs76160063:12267648SYN2G/A0.430.7050.3850.1810.360.9740.9590.836
rs76177217:76122078TMC6C/T0.130.0770.1090.0090.130.4800.3610.861
rs77569926:20679709CDKAL1G/A0.270.1800.0940.2920.420.8560.9970.995
rs81926753:170724883SLC2A2C/T0.305.4E-056.1E-050.0100.290.2320.2390.024
rs83776316:88853729CDT1C/T0.440.5910.8040.0460.560.4920.5540.533
rs8576911:158626378SPTA1T/C0.250.8030.4925.6E-060.300.0920.2260.894
rs960457313:114542858GAS6A/G0.260.4820.3000.6870.240.9020.8330.425
rs98187583:49382925USP4A/G0.170.2400.8700.7800.090.2970.2970.642
rs991498817:27183104ERAL1G/A0.210.3070.9930.0580.660.2520.0800.342
  • freq, frequency. Candidate SNPs selected from NHGRI database based on previous genome-wide significant associations. P values that reach study-wide significance for fructosamine and glycated albumin, P < 2.7 × 10−4 (0.05/(2*2*46)), and P values that reach nominal significance (P < 0.05) for HbA1c are in boldface type.