Table 1

Physiological measurements in mice at 6 months of age

WTAkitaRenTgAkita-RenTg
C57BL/6 (n = 7)1129/SvEv (n = 7)1C57BL/6 (n = 6)1129/SvEv (n = 5)1C57BL/6 (n = 8)129/SvEv (n = 7)C57BL/6 (n = 6)129/SvEv (n = 12)
Body weight (g)27.3 ± 0.624.9 ± 0.8426.4 ± 0.7026.8 ± 0.7027.4 ± 0.7926.6 ± 0.6425.9 ± 0.6223.3 ± 0.47
Blood glucose (mg/dL)133 ± 898 ± 3518 ± 25*496 ± 32*146 ± 791 ± 4566 ± 3*435 ± 12*
Urine volume (mL)1.2 ± 0.21.2 ± 0.221.2 ± 1.9,18.2 ± 1.1,§3.5 ± 0.71.7 ± 0.113.9 ± 1.810.5 ± 1.7
Left kidney weight (mg)162 ± 4151 ± 5208 ± 10258 ± 13164 ± 11166 ± 3218 ± 9232 ± 8
Mesangial score0.37 ± 0.040.48 ± 0.070.94 ± 0.061.05 ± 0.060.55 ± 0.080.89 ± 0.040.82 ± 0.111.22 ± 0.02*
Glomerular volume0.26 ± 0.010.18 ± 0.010.36 ± 0.01*0.30 ± 0.020.29 ± 0.020.30 ± 0.020.41 ± 0.020.41 ± 0.02
AE (µg/24 h)14.3 ± 2.233 ± 2039.9 ± 3.2151 ± 7885.8 ± 29383 ± 42398 ± 943,456 ± 702
ACR (µg/mg)25.4 ± 1.750.2 ± 2618.6 ± 2.2161 ± 71151.8 ± 29565 ± 65158.6 ± 542,948 ± 598§,
  • ACR, albumin-to-creatinine ratio.

  • *P < 0.05 compared with WT same strain.

  • P < 0.001 compared with WT same strain.

  • §P < 0.001, same genotype compared with C57BL/6 strain.

  • P < 0.05 compared with same strain WT and RenTg.

  • P < 0.05 compared with Akita-RenTg same strain.

  • 1Included for comparison, as published in Pichaiwong et al. (20).