Table 1

Physiologic characteristics related to lipid metabolism in chow- and HFD-fed mice

Chow-fedHFD-fed
VehicleAnacetrapibVehicleAnacetrapib
Body weight (g)25.5 ± 1.326.1 ± 1.736.2 ± 4.7^42.5 ± 5.5^
Adiposity (%)10.9 ± 0.811.4 ± 2.237.6 ± 6.1^40.1 ± 4.1^
Blood
 Glucose (mg/dL)63.4 ± 17.163.7 ± 7.891.2 ± 11.8^87.7 ± 14.7^
 Cholesterol (mg/dL)68.5 ± 13.4101.5 ± 10.4*116 ± 4.2^118 ± 3.8^
 TGs (mg/dL)58.8 ± 14.454.8 ± 7.862.7 ± 4.1^77.8 ± 8.2^
 Insulin (pg/mL)689 ± 279878 ± 61,530 ± 235^1,970 ± 268^
 IL-6 (pg/mL)137 ± 31189 ± 29196 ± 65^323 ± 77^*
 Resistin (pg/mL)2,202 ± 3751,818 ± 2703,110 ± 601^4,560 ± 732^*
 Leptin (pg/mL)530 ± 287304 ± 1073,582 ± 547^5,183 ± 2,154^
 LCAT activity (mU/mL)305 ± 39348 ± 33336 ± 67389 ± 26
 LPL activity (mU/mL)0.26 ± 0.060.27 ± 0.040.41 ± 0.11^0.39 ± 0.06^
 PLTP activity (pmol FIU transferred/mL)160 ± 14150 ± 5.9183 ± 1.2^199 ± 12^
  • Data are mean ± SD. Statistical analysis was performed using two-way ANOVA with Bonferroni multiple comparison test. FIU, fluorescence intensity units.

  • *P < 0.05 compared with respective vehicle controls.

  • ^P < 0.05 compared with chow-fed mice.