Table 1

Baseline characteristics over IGFBP-2 quintile-based groups, EPIC-Potsdam Study (subcohort, n = 2,108)

Subgroups according to quintiles of IGFBP-2
Q1*
(n = 422)Q2
(n = 421)Q3
(n = 422)Q4
(n = 421)Q5
(n = 422)All
IGFBP-2, ng/mL41 (1–54)65 (54–78)92 (78–105)121 (105–142)175 (142–666)92 (59, 129)
Sex, female %676362606062
Age at baseline, years45 (40, 54)48 (41, 57)51 (43, 59)52 (43, 59)54 (44, 60)50 (42, 58)
BMI, kg/m228 (25, 31)27 (24, 30)26 (23, 28)25 (23, 27)23 (21, 26)26 (23, 28)
Waist, cm91 (79, 101)88 (77, 96)86 (77, 94)83 (75, 91)79 (71, 87)85 (75, 94)
Activity, h/week4 (2, 7)5 (2, 8)5 (2, 8)5 (2, 9)5 (2, 9)5 (2, 8)
Smoking status, %
 Never smoker454951504648
 Ex-smoker, <20 units/day252422222123
 Ex-smoker, ≥20 units/day14118759
 Smoker, <20 units/day121215141914
 Smoker, ≥20 units/day354796
Education, %
 Vocational training or lower423338373837
 Technical college232424282224
 University354338364038
Alcohol use, g/day8.5 (3.1, 20.6)8.9 (3.4, 20.1)7.3 (2.2, 16.9)8.7 (3, 20.6)6.9 (2.2, 16.5)8.2 (2.6, 19.4)
IGF-1, ng/mL162 (128, 206)172 (137, 210)167 (135, 203)162 (135, 199)150 (126, 184)163 (133, 201)
IGFBP-3, µg/mL3.1 (2.8, 3.5)3.1 (2.8, 3.5)3.1 (2.7, 3.5)3 (2.7, 3.4)3.1 (2.7, 3.5)3.1 (2.7, 3.5)
Triglycerides, mg/dL133 (92, 199)119 (83, 180)106 (77, 158)98 (69, 137)88 (64, 129)107 (77, 161)
Fetuin A, µg/mL288 (248, 335)266 (227, 312)263 (220, 299)258 (223, 301)250 (212, 290)265 (226, 307)
ALT, units/L22 (15, 37)21 (15, 31)20 (15, 28)19 (14, 24)17 (14, 22)20 (15, 28)
γ-GT, units/L23 (13, 42)19 (13, 40)17 (12, 28)14 (9, 26)14 (9, 22)17 (11, 31)
FLI53 (16, 80)39 (12, 67)26 (10, 55)19 (6, 41)10 (5, 30)26 (8, 58)
Adiponectin, µg/mL6.7 (4.9, 8.9)7.2 (5.3, 9.8)7.9 (5.8, 10.4)8.6 (5.9, 11.7)9.2 (6.5, 12.7)7.8 (5.7, 10.7)
Glucose, mg/dL102 (94, 113)101 (93, 110)101 (96, 110)102 (92, 110)99 (91, 108)101 (94, 110)
HbA1c, %5.5 (5.2, 5.8)5.4 (5.1, 5.8)5.4 (5.1, 5.7)5.4 (5.1, 5.7)5.4 (5.1, 5.7)5.4 (5.1, 5.7)
HbA1c, mmol/mol36.1 (33, 40)35.4 (32.2, 39.6)35.4 (32.2, 39)35.3 (32.3, 38.8)35.3 (32.6, 38.5)35.5 (32.5, 39.1)
  • Data are median (minimum–maximum), median (interquartile range), or %.

  • *The representative subcohort was divided into five subgroups (Q1–Q5) according to quintiles of the distribution of IGFBP-2 plasma concentrations.