Table 1

Distribution of features among the multiple autoantibody clusters

Autoantibody clusters
All clustersmC1mC2mC3mC4mC5mC6mC7mC8mC9mC10mC11mC12
Children, n370353012212788272416301941
Age (years) at seroconversion, median (IQR)2.0 (1.1–3.1)4.0 (3.0–4.7)4.2 (2.8–5.5)1.0 (0.8–2.0)7.2 (3.3–7.5)1.0 (0.8–1.1)1.4 (0.8–1.8)3.3 (3.0–3.9)2.4 (1.8–2.9)2.5 (2.3–3.0)1.7 (1.0–2.2)1.6 (1.1–2.0)1.5 (1.0–2.3)
T1D prevalence4111175014856674612632132
5-Year T1D risk, % (95% CI)44 (38–49)12 (0–23)28 (0–49)51 (5–75)26 (0–49)84 (59–94)63 (51–72)9 (0–21)53 (21–72)6 (0–17)41 (20–57)22 (0–39)40 (19–56)
Maternal T1D614108075446305
HLA
 HLA-DR3/DR37938503403117217
 HLA-DR3/DR457696333484464563856436863
 HLA-DR4/DR41817233314151026421327015
 HLA-DR4/DRx186102533412215210131115
ZnT8A62517383524458747175774756
Born by cesarean delivery22262050243717261725201620
Male sex56575083527455526769504741
  • Data are percentages unless otherwise indicated. IQR, interquartile range; T1D, type 1 diabetes.