Table 4

Methylation score and type 2 diabetes risk

ExposureAdditionally adjusted for…OR per SD*95% CI
Methylation score2.712.12, 3.46
IGFBP-22.832.1, 3.81
Waist circumference3.152.25, 4.42
FLI3.252.25, 4.68
HbA1c and glucose2.571.83, 3.61
  • DNA methylation of the IGFBP-2 gene in relation to type 2 diabetes risk was evaluated in a 1:1 matched case-control study (analytical sample n = 290 case subjects and n = 290 control subjects), nested within the EPIC-Potsdam cohort study. Control subjects were drawn by incidence density sampling and matched for age (±6 months), sex, fasting time (<3 h, 3 to <6 h, and ≥6 h before blood draw), time of day of blood sampling (±2 h), and season at blood sampling.

  • *OR of developing type 2 diabetes associated with 1 SD higher methylation score; all models were adjusted for alcohol consumption, smoking, and physical activity as well as age and sex (matching variables).