Table 4

Variants with P < 5 × 10⁻⁸ (traditional, nominal threshold for genome-wide significance) in the discovery analyses

Case-control definition	Population/LT modeling	RSID	CHR	Position	Nearest gene	REF	Case subjects		Control subjects		NEFF	P	OR	95% CI
Case-control definition	Population/LT modeling	RSID	CHR	Position	Nearest gene	REF	N	RAF	N	RAF	NEFF	P	OR	95% CI
PDR	AA/no	rs115523882	3	167876205	GOLIM4	A	1,105	0.9823	1,119	0.9611	1,452	9.42 × 10⁻⁹	3.10	2.12, 4.53
PDR	AA/yes	rs115523882	3	167876205	GOLIM4	A	1,105	0.9823	1,119	0.9611	1,452	5.37 × 10⁻⁹	3.10	2.14, 4.50
PDR	EUR/no	rs139205645	2	201949806	NDUFB3	T	309	0.9725	975	0.9959	907	3.93 × 10⁻⁸	0.13	0.06, 0.27
PDR	EUR/yes	rs17791488	17	26232732	NOS2/LYRM9	T	309	0.9871	975	0.9661	907	7.26 × 10⁻⁹	3.70	2.40, 5.71
Extremes of DR	AA/no	rs184340784	1	4589883	AJAP1	C	520	0.999	230	0.9784	603	3.52 × 10⁻⁸	NA	NA
Extremes of DR	EUR/yes	rs142293996	1	224448059	NVL	C	187	0.9947	435	0.9874	523	2.10 × 10⁻⁹	2.38	1.80, 3.14
Extremes of DR	EUR/yes	rs17706958	3	73837141	PDZRN3	T	308	0.8139	594	0.7332	797	3.04 × 10⁻⁸	1.58	1.35, 1.85
Extremes of DR	EUR/yes	rs80117617	2	40855125	SLC8A1	T	308	0.9838	594	0.9445	797	4.04 × 10⁻⁸	3.78	2.37, 6.02

AA, African American; CHR, chromosome; EUR, European; LT, liability threshold; NA, not available; NEFF, effective sample size; RAF, reference allele frequency; REF, reference allele; RSID, rs identifier.