Table 4

Variants with P < 5 × 10−8 (traditional, nominal threshold for genome-wide significance) in the discovery analyses

Case-control definitionPopulation/LT modelingRSIDCHRPositionNearest geneREFCase subjectsControl subjectsNEFFPOR95% CI
NRAFNRAF
PDRAA/nors1155238823167876205GOLIM4A1,1050.98231,1190.96111,4529.42 × 10−93.102.12, 4.53
PDRAA/yesrs1155238823167876205GOLIM4A1,1050.98231,1190.96111,4525.37 × 10−93.102.14, 4.50
PDREUR/nors1392056452201949806NDUFB3T3090.97259750.99599073.93 × 10−80.130.06, 0.27
PDREUR/yesrs177914881726232732NOS2/LYRM9T3090.98719750.96619077.26 × 10−93.702.40, 5.71
Extremes of DRAA/nors18434078414589883AJAP1C5200.9992300.97846033.52 × 10−8NANA
Extremes of DREUR/yesrs1422939961224448059NVLC1870.99474350.98745232.10 × 10−92.381.80, 3.14
Extremes of DREUR/yesrs17706958373837141PDZRN3T3080.81395940.73327973.04 × 10−81.581.35, 1.85
Extremes of DREUR/yesrs80117617240855125SLC8A1T3080.98385940.94457974.04 × 10−83.782.37, 6.02
  • AA, African American; CHR, chromosome; EUR, European; LT, liability threshold; NA, not available; NEFF, effective sample size; RAF, reference allele frequency; REF, reference allele; RSID, rs identifier.