Table 6

Replication results for variants with nominal significance (P < 0.05) in the combined (Hispanic, African American, and European cohorts) replication meta-analyses

Discovery population/LT modelingRSIDNearest geneREF*Disc EAFDisc ORDisc PAll rep ORAll rep PDisc + rep ORDisc + rep P
Variants identified in the any DR discovery analysis
  European (Sens)/nors1394919PPEF2/NAAAC0.720.738.51 × 10−60.910.0030.886.35 × 10−6
  AA (Sens)/nors75360147SLC28A3T0.932.087.07 × 10−62.650.0092.172.29 × 10−7
  European/nors1508244HTR1EA0.980.333.74 × 10−60.920.010.900.002
  ME/nors10432638UBXN2AC0.730.782.60 × 10−60.930.010.897.74 × 10−6
  EU/nors150775408BC031225C0.951.977.24 × 10−61.270.041.462.54 × 10−5
  AA/yesrs143894698GCM1G0.983.144.62 × 10−61.450.0041.582.53 × 10−5
  European/yesrs13006587ATAD2BG0.580.797.52 × 10−60.930.0060.924.74 × 10−5
  European/yesrs73642012PTPRDC0.910.679.58 × 10−60.900.020.878.67 × 10−5
Variants identified in the PDR discovery analysis
  Europeans/nors139921826PRSS35G0.980.337.92 × 10−60.660.030.620.0008
  AA/yesrs1414474C1orf94C0.141.621.46 × 10−71.120.011.191.90 × 10−5
  AA/yesrs9998354BTF3P13T0.440.738.74 × 10−60.920.040.870.0001
  European/yesrs142293996NVLC0.991.831.14 × 10−62.400.042.290.0001
Variants identified in the NPDR discovery analysis
  European/nors1508244RN7SL643PA0.980.328.13 × 10−60.890.0050.870.0005
  European/nors7944308KCNA4G0.420.717.76 × 10−70.940.020.905.80 × 10−5
Variants identified in the extremes of DR discovery analysis
  AA/nors74161190TCERG1LA0.940.324.57 × 10−60.400.030.327.16 × 10−7
  European/yesrs17706958PDZRN3T0.761.583.04 × 10−81.280.021.397.41 × 10−8
  European/yesrs10932347CPS1A0.040.334.22 × 10−70.640.020.551.30 × 10−5
  AA/yesrs2690028KAZNC0.320.624.52 × 10−60.800.030.741.72 × 10−5
  European/yesrs116972715DSC3C0.992.602.48 × 10−63.620.033.291.59 × 10−5
  European/yesrs75167957CTNNA2C0.993.263.36 × 10−69.770.046.345.83 × 10−6
  AA/yesrs6577631LOC339862G0.860.533.45 × 10−60.890.040.840.0006
  • AA, African American; All rep, all replication cohorts; Disc, discovery; ME, multiethnic; REF, reference allele; Rep, replication; Sens, sensitivity analysis.

  • *For insertion-deletions, the reference allele is shown first followed by the alternate allele.