Table 3

Cox proportional hazards models for developing islet autoantibodies and diabetes in FDR children compared with GP children (reference)

One or more islet autoantibodiesMultiple islet autoantibodiesDiabetes
Model 1*Model 2*Model 1*Model 2*Model 1*Model 2*
HR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
FDR child2.12 (1.65–2.72)<0.00011.82 (1.42–2.35)<0.00012.77 (2.09–3.68)<0.00012.26 (1.70–3.02)<0.00013.69 (2.60–5.23)<0.00012.92 (2.05–4.16)<0.0001
DRB1*04:01/x1.42 (1.10–1.83)0.00751.48 (1.08–2.01)0.0141.38 (0.93–2.04)0.1052
Genetic risk score1.48 (1.34–1.64)<0.00011.66 (1.47–1.88)<0.00011.67 (1.42–1.96)<0.0001
BTNL2 rs3763305 GG§1.05 (0.79–1.40)0.731.39 (0.96–2.00)0.0801.80 (1.11–2.93)0.0175
ITGA1 rs7735139 GG§1.18 (0.86–1.63)0.301.06 (0.70–1.60)0.771.11 (0.67–1.87)0.6776
  • *Model 1 and 2 are adjusted for sex, country (reference: U.S.), and HLA genotype (reference: DR4-DQ8/DR4-DQ8).

  • †Reference: DRB1 without 04:01 or 04:01/04:04 and 04:01/04:07.

  • ‡Per unit increase.

  • §Reference: GA/AA genotype.