Table 2

Allelic enrichment of DRB1*04 subtypes in FDR children

DR4 subtypeFDR children (alleles, n = 535)GP children (alleles, n = 5,415)P*
DRB1*04:01329 (60.15)2,788 (51.49)<0.0001
DRB1*04:0233 (6.03)291 (5.37)0.42
DRB1*04:04137 (25.05)1,928 (35.60)<0.0001
DRB1*04:0523 (4.20)226 (4.17)0.91
DRB1*04:061 (0.18)1 (0.02)0.17
DRB1*04:077 (1.28)153 (2.83)0.035
DRB1*04:084 (0.73)25 (0.46)0.33
DRB1*04:100 (0.00)1 (0.02)1
DRB1*04:111 (0.18)1 (0.02)0.17
DRB1*04:130 (0.00)1 (0.02)1
  • Data are n (%). Each DRB*04 allele was counted separately (once for children with the DR3/DR4-DQ8 genotype and twice for children with the DR4-DQ8/DR4-DQ8 genotype). DRB*04 subtype information was missing in 77 DR3/DR4-DQ8 and 35 DR4-DQ8/DR4-DQ8 children. Children with the nonrisk DRB1*04:03 allele were excluded a priori from the TEDDY study unless they had a first-degree relative with type 1 diabetes, and the 12 occurrences of this allele in FDR children were therefore not considered.

  • *P values were calculated using Fisher test.