Table 4

BTNL2 SNP genotype frequencies in relation to the development of islet autoantibodies and diabetes among TEDDY children with HLA DR3/DR4-DQ8 or DR4-DQ8/DR4-DQ8 and available genotype information

Islet autoantibody negativeOne or more islet autoantibodiesMultiple islet autoantibodiesDiabetes
HLA DR3/4-DQ8 (n = 3,024), BTNL2 SNP rs3763305
 GG1,839 (69.1)272 (75.3)190 (79.8)120 (82.8)
 GA823 (30.9)89 (24.7)48 (20.2)25 (17.2)
 AA1 (0.0)0 (0.0)0 (0.0)0 (0.0)
 P*0.0300.00070.0007
HLA DR4-DQ8/DR4-DQ8 (n = 1,532), BTNL2 SNP rs3763305
 GG692 (49.7)89 (64.0)63 (73.3)36 (76.6)
 GA571 (41.0)44 (31.7)21 (24.4)10 (21.3)
 AA130 (9.3)6 (4.3)2 (2.3)1 (2.1)
 P*0.0033<0.00010.0010
  • Data are n (%).

  • *Children who remained islet autoantibody negative were compared with children who developed one or more islet autoantibodies, multiple islet autoantibodies, and diabetes using Fisher test.