Table 1

Study characteristics by first-degree relative status

VariableFDR children (n = 423)GP children (n = 4,149)
Males200 (47.3)2,082 (50.2)
HLA genotype
 DR3/4-DQ8280 (66.2)2,755 (66.4)
 DR4-DQ8/DR4-DQ8143 (33.8)1,394 (33.6)
Country
 U.S.194 (45.9)1,750 (42.2)
 Finland51 (12.1)792 (19.1)
 Germany92 (21.7)209 (5.0)
 Sweden86 (20.3)1,398 (33.7)
First-degree relative with T1D
 None0 (0.0)4,149 (100.0)
 Mother146 (34.5)0 (0.0)
 Father180 (42.6)0 (0.0)
 Sibling79 (18.7)0 (0.0)
 Multiplex18 (4.3)0 (0.0)
Outcome events
 One or more islet  autoantibodies85 (20.1)415 (10.0)
 Multiple islet autoantibodies69 (16.3)255 (6.1)
 First-appearing IAA51 (12.1)227 (5.5)
 First-appearing GADA46 (10.9)250 (6.0)
 Diabetes47 (11.1)145 (3.5)
Genetic risk score available408 (96.5)4,006 (96.6)
  • Data are n (%).