Table 2

Liver fat and body composition before and after 7 weeks of PUFA or SFA overeating

PUFA (n = 18) baselineMean absolute changeSFA (n = 19) baselineMean absolute changeMean difference in change (95% CI)P value
Body weight, kg67.4 ± 8.21.6 ± 0.8563.3 ± 6.81.6 ± 0.96−0.02 (−0.63 to 0.58)0.94
BMI, kg/m220.8 (19.5–23.1)0.5 ± 0.319.9 (18.9–20.7)0.5 ± 0.30.01 (−0.18 to 0.20)0.98
Waist girth, cm79.4 ± 5.60.97 ± 2.276.1 ± 5.11.0 ± 2.3−0.03 (−1.53 to 1.47)0.97
Liver fat, % (MRI)0.75 (0.65–1.0)0.04 ± 0.240.96 (0.79–1.1)0.56 ± 1.0−0.52 (−1.0 to −0.01)0.033
Lean tissue, L (MRI)43.4 ± 8.40.86 ± 0.6241.8 ± 6.90.31 ± 0.680.55 (0.11–0.98)0.015
VAT, L (MRI)0.99 (0.50–1.6)0.11 ± 0.210.81 (0.52–1.0)0.22 ± 0.16−0.12 (−0.24 to 0.01)0.035
VAT/SAT ratio (MRI)*0.08 ± 0.040.00 ± 0.010.07 ± 0.030.01 ± 0.01−0.01 (−0.02 to 0.00)0.073
Abdominal SAT, L (MRI)2.2 (1.9–3.1)0.25 ± 0.321.8 (1.5–2.8)0.34 ± 0.23−0.09 (−0.27 to 0.10)0.32
Total body fat, L (MRI)14.4 (12.6–19.6)0.97 ± 1.012.9 (10.4–18.2)1.5 ± 0.70−0.57 (−1.2 to 0.01)0.013
Lean tissue, % (Bod Pod)81.9 ± 6.3−0.81 ± 1.285.6 ± 7.4−1.7 ± 1.10.93 (0.15–1.70)0.021
Total body fat, % (Bod Pod)18.1 ± 6.30.81 ± 1.214.4 ± 7.41.7 ± 1.1−0.93 (−1.70 to −0.15)0.021
  • Data are means ± SD or median (IQR) and 95% CI. For nonnormal variables, P values are obtained from nonparametric analyses. Mean difference in change is calculated as mean absolute change in PUFAs minus mean absolute change in SFAs.

  • *Calculated as VAT/(TAT − VAT).