Table 1

Names and characteristics of large clinical studies in diabetes

AcronymStudy titleArea of interestStudy populationReference
ACCORDAction to Control Cardiovascular Risk in DiabetesOutcomes of hyperglycemia treatment and lipid lowering in diabetes5,518 patients with type 2 diabetes and receiving open-label simvastatin41
ADVANCEAction in Diabetes and Vascular DiseaseOutcomes of hyperglycemia treatment and blood pressure lowering in diabetes11,140 patients with type 2 diabetes46
BARI 2DBypass Angioplasty Revascularization Investigation in 2 DiabetesCAD treatment2,368 patients with type 2 diabetes and heart disease44
DISTANCEDiabetes Study of Northern CaliforniaHealth disparitiesMore than 2 million adults enrolled in Kaiser Permanente Northern California in 2010, including more than 210,000 patients with prevalent diabetes and more than 15,000 incident cases in the calendar year7
DPPDiabetes Prevention ProgramEffects of lifestyle vs. metformin on progression to diabetes3,234 overweight individuals with prediabetes5
Look AHEADAction for Health in DiabetesEffects of intervention on cardiovascular morbidity and mortality5,145 overweight adults with diabetes38