Table 2

The present scenario: α-cell/area and quantification data on human pancreata

α-Cell quantification studyUnitIndividuals without diabetesIncrease (%)Individuals with diabetesIncrease (%)α-cell/β-cell increase (%)
Henquin and Rahier (6)Mass0.347 ± 0.183 g0.366 ± 0.186 gNS30
Inaishi et al. (7)% per total pancreas area0.49 ± 0.44%0.35 ± 0.31%NS11
Yoon et al. (5)% per islet16.6 ± 2.8%26.1 ± 6.1%9.5 (1.6-fold change)52
Marselli et al. (4)% per islet20.2 ± 5.3%23.3 ± 5.4%NS15
Cinti et al. (3)% per islet22.75 ± 1.6%37.36 ± 1.5%14.61 (1.6-fold change)30
Mezza et al. (11)% per total pancreas areaInsSens 0.04 ± 0.01%InsRes 0.23 ± 0.06%0.19 (5.7-fold change)14
  • Data are means ± SE. InsRes, insulin resistant; InsSens, insulin sensitive. Henquin and Rahier (6) used the traditional method of measurement of α-cell mass. The other studies describe percentages of islet or total pancreas area occupied by α-cells as a surrogate for the total mass of endocrine cells.