Table 1

The present scenario: β-cell/area and quantification data on human pancreata

β-Cell quantification studyUnitControl subjectsChange within control subjects (%)DiabetesReduction diabetes vs. control subjects
(%)
Rahier et al. (1)Mass per pancreas0.888 ± 0.304 g0.573 ± 0.259 g36
Butler et al. (2)% per islet52.0 ± 4.1% (lean)38.0 ± 3.9% (lean)26
Butler et al. (2)% per islet45.4 ± 2.7% (obese)37.0 ± 2.3% (obese)17.7
Inaishi et al. (7)% per total pancreas area1.48 ± 1.08%0.80 ± 0.54%46
Yoon et al. (5)% per islet59.0 ± 10.3%38.3 ± 12.4%35.5
Marselli et al. (4)% per islet72.1 ± 8.7%54.9 ± 6.3%24
Cinti et al. (3)% per islet77.2 ± 1.8%53.1 ± 3.7%31
Yoneda et al. (12)% per total pancreas areaNGT 1.60 ± 0.45%
IGT 0.99 ± 0.51%38NewOns 0.93 ± 0.23%
Longst 0.53 ± 0.1%43
Mezza et al. (11)% per total pancreas areaInsSens 0.58 ± 0.17%
InsRes 1.10 ± 0.23%47
  • Data are means ± SE. InsRes, insulin resistant; InsSens, insulin sensitive; Longst, long-standing; NewOns, new onset. Rahier et al. (1) used the traditional method of measurement of β-cell mass. The other studies describe percentages of islet or total pancreas area occupied by β-cells as a surrogate for the total mass of endocrine cells.