Table 2

Top 10 ranked Matsuda insulin sensitivity–correlated cis-eGenes in adipose tissue from African American (AAGMEx cohort) and European ancestry (METSIM) individuals

Gene symbolChrAAGMEx cohortMETSIM cohort
Matsuda insulin sensitivity indexeQTL analysisMatsuda insulin sensitivity indexeQTL analysis
ρPProbe IDTop cis-eSNPA1MAFβ*eQTL_ P valueβP valueProbeset IDTop cis-eSNPalt_ alleleMAFβ*eQTL_ P value
ECHDC3100.4715.33E-15ILMN_2072178rs200943982T0.401−0.2811.94E-090.3422.35E-2211728810_a_atrs3814627G0.312−0.7558.3E-52
MIF22−0.3902.26E-10ILMN_1807074rs4822455T0.435−0.1884.56E-13−0.2575.64E-1311744470_x_atrs4822443A0.225−0.9891.3E-78
CENPV170.4111.86E-11ILMN_3246608rs3112521T0.4270.1075.83E-090.2884.85E-1611722721_a_atrs3112526C0.4850.7512.3E-53
DDT220.3624.71E-09ILMN_1690982rs79966373G0.178−0.3022.81E-140.2775.30E-1511731089_a_atchr22:24334948C0.353−1.0551E-125
APOB20.4016.50E-11ILMN_1664024rs1429974T0.2410.2935.28E-090.2567.13E-1311758033_s_atrs11693870C0.2650.9509E-72
ORMDL3170.4452.24E-13ILMN_1662174rs28820390A0.091−0.3553.37E-070.3921.52E-2911736188_a_atrs2872516T0.495−0.5651.2E-29
GLIPR112−0.4583.55E-14ILMN_1769245rs117251563A0.0130.7058.07E-07−0.2171.30E-0911721839_atrs35619460C0.194−1.4451E-158
ACSS3120.4491.32E-13ILMN_1659885rs4842386G0.167−0.1116.97E-060.3322.99E-2111759049_atrs3794325A0.332−0.9195.9E-81
ITIH510−0.4349.54E-13ILMN_1731862rs201694044G0.375−0.1545.05E-07−0.3252.66E-2011734677_x_atrs867490G0.3120.6106.8E-33
DMRT290.4016.05E-11ILMN_1751785rs756145G0.3150.2822.77E-080.3001.80E-1711727728_a_atrs10959032T0.271−0.6999.4E-37
  • Matsuda insulin sensitivity–correlated transcripts of Entrez ID genes in adipose tissue associated with a SNP (q value <0.04) within ±500 Kb of the 5′ and 3′ end of the transcript in AAGMEx are shown. Data for most significantly associated genotyped cis-eSNP in AAGMEx are presented. Data on European ancestry males are from the METSIM cohort (Civelek et al. [20]). In AAGMEx: ρ, Spearman partial correlation coefficient; P value, significance level of correlation of transcript level with Matsuda index in Spearman partial correlation analysis; A1, minor allele; β, effect size of minor allele (A1); eQTL_P value, significance in additive model (in MatrixEQTL analysis). In METSIM: β, β value; P value, significance level of correlation of transcript level with Matsuda index in linear regression analysis; alt_allele, alternative allele; β*, effect size for alternative allele of best cis-eSNP in FaST-LMM eQTL analysis. Results for all significant probes are shown in Supplementary Table 4. Top cis-eSNPs are not the same in both cohorts, but comparison of their effects is shown in Supplementary Table 4A and B and in Supplementary Fig. 3. Chr, chromosome.