Table 3

Bias in proposed vs. published responder criteria

Assumed percent maintaining C-peptide at 6 months
Criterion20%30%40%50%60%
100%+0.2+0.0−0.4+0.0−0.3
92.5%+4.0+4.9+4.9+5.30+4.9
87.2%+7.4+8.7+9.1+9.3+8.6
Assumed percent maintaining C-peptide at 1 year
 Criterion20%30%40%50%60%
100%+0.0−0.3+0.1−0.2−0.1
92.5%+2.0+2.0+2.7+2.5+2.6
87.2%+3.5+3.9+4.8+4.5+4.5
Assumed percent maintaining C-peptide at 2 years
 Criterion20%20%20%20%20%
100%−0.1−0.3−0.1+0.0−0.0
92.5%+1.8+2.0+2.5+2.8+2.6
87.2%+3.4+4.0+4.5+4.9+4.5
  • Values denoted by + (or −) “0.0” were such that they were slightly above (below) zero and rounded to zero.

  • †Bias is defined to be proportion in excess (+) or in deficit (−) of the assumed percent retaining C-peptide in the population.