Table 1

Summary of the two sets of insulin-reactive CD4 T cells

RegisterB:12–20B:13–21
SequenceSHLVEALYLVCGERGSHLVEALYLVCGERG
AffinityLowHigh
Dissociation rateFastSlow
Native insulinNoYes
Insulin peptidesYesYes
Internal processingEliminatedSelected
Sites of presentationIslet/peripheryIslets/periphery
T-cell reactivityStrongMinimal
DiabetogenicityStrongUndetermined