Table 2

MR analysis of the effect of insulin resistance (proxied by circulating fasting insulin) on liver function markers

OutcomeMethodβ95% CIP
ALTIVW0.460.22, 0.690.0001
MR-Egger0.14−1.15, 1.420.84
Weighted median0.430.10, 0.760.01
IVW adjusted by BMI0.470.21, 0.720.0004
ASTIVW0.31−0.1, 0.710.14
MR-Egger−1.01−3.31, 1.290.41
Weighted median0.32−0.26, 0.890.28
IVW adjusted by BMI0.25−0.22, 0.720.30
ALPIVW−0.14−0.78, 0.490.66
MR-Egger3.390.37, 6.410.05
Weighted median−0.40−0.88, 0.070.09
IVW adjusted by BMI−0.21−0.6, 0.180.29
GGTIVW0.28−0.24, 0.80.3
MR-Egger−2.35−4.95, 0.250.10
Weighted median0.510.18, 0.840.003
IVW adjusted by BMI0.22−0.1, 0.540.18
  • Results correspond to mean difference (in SD units) of log10 liver function marker (95% CI) per 1 SD increase in fasting insulin (in pmol/L).