Table 4

Association between the IC biomarkers and the risk of MI events in unadjusted, minimally adjusted, and final adjusted Cox models

UnadjustedAdjusted for age and HbA1cFinal models*
HR (95% CI)**P valueHR (95% CI)**P valueHR (95% CI)**P value
DCCT baseline (36 events, n = 518)
 AGE-LDL-IC (mg/L)1.53 (1.12, 2.11)0.0081.48 (1.07, 2.04)0.0181.42 (1.02, 1.99)0.040
 MDA-LDL-IC (mg/L)1.35 (1.04, 1.76)0.0271.36 (1.02, 1.80)0.0351.32 (0.98, 1.77)0.069
 oxLDL-IC (mg/L)1.94 (1.33, 2.83)0.0011.86 (1.27, 2.72)0.0011.75 (1.18, 2.58)0.005
DCCT closeout (33 events, n = 504)
 AGE-LDL-IC (mg/L)1.47 (1.04, 2.07)0.0281.40 (0.99, 2.00)0.0611.27 (0.88, 1.83)0.210
 MDA-LDL-IC (mg/L)1.40 (1.06, 1.86)0.0191.40 (1.03, 1.90)0.0341.26 (0.92, 1.71)0.150
 oxLDL-IC (mg/L)1.97 (1.31, 2.95)0.0011.83 (1.21, 2.75)0.0041.65 (1.09, 2.49)0.018
All measurements (36 events, n = 518)
 AGE-LDL-IC (mg/L)1.45 (1.03, 2.05)0.0351.34 (0.94, 1.92)0.1131.26 (0.87, 1.81)0.223
 MDA-LDL-IC (mg/L)1.34 (0.97, 1.84)0.0731.28 (0.92, 1.77)0.1461.20 (0.87, 1.64)0.263
 oxLDL-IC (mg/L)1.77 (1.16, 2.70)0.0081.56 (1.03, 2.36)0.0381.45 (0.96, 2.19)0.079
  • P values <0.05 are presented in boldface type.

  • *Adjusted for age, mean HbA1c, mean LDL, and (log) AER. The number of covariates was reduced in the final models due to the small number of events (see research design and methods).

  • **Per 1 unit increase in the log-transformed biomarker value. The HR per (for example) a 25% increase in the biomarker (or, equivalently, a 1.25-fold change) is given by HR^log(1.25), where “^” denotes “to the power of.” Biomarkers are noted amount per milligram of apoB contained in the IC, using serum total apoB/L.