Table 3

Association between the IC biomarkers and the risk of MACCE in unadjusted, minimally adjusted, and final adjusted Cox models

UnadjustedAdjusted for age and HbA1cFinal models*
HR (95% CI)**P valueHR (95% CI)**P valueHR (95% CI)**P value
DCCT baseline (46 events, n = 518)
 AGE-LDL-IC (mg/L)1.47 (1.13, 1.93)0.0051.42 (1.01, 1.87)0.0121.34 (0.99, 1.80)0.051
 MDA-LDL-IC (mg/L)1.30 (1.04, 1.63)0.0211.30 (1.03, 1.65)0.0291.23 (0.95, 1.60)0.109
 oxLDL-IC (mg/L)1.78 (1.26, 2.51)0.0011.72 (1.22, 2.42)0.0021.57 (1.10, 2.25)0.014
DCCT closeout (43 events, n = 504)
 AGE-LDL-IC (mg/L)1.37 (1.01, 1.86)0.0451.29 (0.95, 1.76)0.1081.16 (0.81, 1.66)0.419
 MDA-LDL-IC (mg/L)1.34 (1.05, 1.71)0.0181.33 (1.02, 1.73)0.0351.23 (0.93, 1.64)0.150
 oxLDL-IC (mg/L)1.87 (1.29, 2.70)0.0011.73 (1.19, 2.51)0.0041.56 (1.05, 2.31)0.028
All measurements (46 events, n = 518)
 AGE-LDL-IC (mg/L)1.44 (1.08, 1.91)0.0121.33 (0.98, 1.79)0.0641.21 (0.90, 1.65)0.224
 MDA-LDL-IC (mg/L)1.34 (1.03, 1.75)0.0291.28 (0.97, 1.68)0.0781.18 (0.90, 1.55)0.238
 oxLDL-IC (mg/L)1.71 (1.20, 2.44)0.0031.50 (1.06, 2.13)0.0221.34 (0.94, 1.90)0.106
  • P values <0.05 are presented in boldface type.

  • *Adjusted for age, mean HbA1c, cohort, sex, mean SBP, pulse, (log) triglycerides, mean LDL, (log) AER, and duration of T1D.

  • **Per 1 unit increase in the log-transformed biomarker value. The HR per (for example) a 25% increase in the biomarker (or equivalently, a 1.25-fold change) is given by HR^log(1.25), where “^” denotes “to the power of.” Biomarkers are amount per milligram of apoB contained in the IC, using serum total apoB/L.