Table 1

Clinical and biochemical characteristics of DBA2J mice

ND-GFPND–sNogo-BD-GFPD–sNogo-B
HbA1c, % (mmol/mol) (n = 16–17/group)4.5 (26) ± 1.7 (18)4.3 (24) ± 1.5 (15)7.7 (60) ± 2.2 (24)*7.5 (59) ± 2.8 (30)**
BW (g) (n = 18–20/group)28.6 ± 2.927.5 ± 3.5623.6 ± 3.9*21.6 ± 4.4**
SBP (mmHg) (n = 7–10/group)112 ± 11111 ± 1198 ± 9*93 ± 12**
Kidney weight/BW (mg/g) (n = 12–18/group)8.7 ± 0.68.5 ± 0.69.9 ± 1.4*10 ± 1.2**
Glomerular volume (µm3) (n = 7–12/group, average 30 glomerular determinations per animal)215,480 ± 45,972231,523 ± 38,702193,193 ± 22,518239,640 ± 51,064
  • Data are expressed as mean ± SD. Clinical and biochemical characteristics in ND and D DBA2/J mice overexpressing sNogo-B in the circulation or control vector (GFP).

  • BW, body weight; SBP, systolic blood pressure.

  • ANOVA with post hoc LSD: *P ≤ 0.01, ND-GFP vs. D-GFP; **P ≤ 0.003, ND–sNogo-B vs. D–sNogo-B.