Table 1

Systemic metabolic parameters

Weight (g)Blood glucose (mg/dL)
Diabetes durationExperimental conditionnFinalBefore treatmentFinal
STZ rats
 4 weeksCONTROL8400 ± 9127 ± 14113 ± 8
DIABETIC8275 ± 14501 ± 31463 ± 18
DIABETIC + LOC INS8282 ± 13490 ± 38465 ± 13
DIABETIC + PHL8282 ± 13492 ± 27237 ± 45
DIABETIC + PHL + LOC INS8259 ± 6555 ± 19155 ± 8
DIABETIC + SYS INS7326 ± 8448 ± 13222 ± 13
 8 weeksCONTROL8475 ± 13154 ± 19140 ± 18
DIABETIC8260 ± 9478 ± 30512 ± 29
DIABETIC + LOC INS7314 ± 22535 ± 34468 ± 25
DIABETIC + PHL9291 ± 21536 ± 27174 ± 18
DIABETIC + PHL + LOC INS10271 ± 13486 ± 33220 ± 19
DIABETIC + SYS INS16365 ± 10526 ± 13174 ± 29
 12 weeksCONTROL8564 ± 19116 ± 5105 ± 2
DIABETIC8302 ± 17453 ± 34425 ± 25
DIABETIC + LOC INS9305 ± 24477 ± 27418 ± 30
DIABETIC + PHL6294 ± 20461 ± 25236 ± 22
DIABETIC + PHL + LOC INS8320 ± 22412 ± 28178 ± 19
DIABETIC + SYS INS9460 ± 9456 ± 26209 ± 29
Ins2Akita mice
 4 weeksCONTROL1021.2 ± 0.3N/A180 ± 8
DIABETIC1021.6 ± 0.7N/A209 ± 32
 8 weeksCONTROL929.4 ± 0.8N/A165 ± 12
DIABETIC1126.0 ± 0.5N/A450 ± 37
 12 weeksCONTROL929.6 ± 0.9N/A177 ± 6
DIABETIC1025.8 ± 0.6N/A545 ± 16
  • Data are mean ± SEM. LOC INS, local insulin; N/A, not applicable; PHL, phloridzin; SYS INS, systemic insulin.