Table 1

Systemic metabolic parameters

			Weight (g)	Blood glucose (mg/dL)
Diabetes duration	Experimental condition	n	Final	Before treatment	Final
STZ rats
4 weeks	CONTROL	8	400 ± 9	127 ± 14	113 ± 8
	DIABETIC	8	275 ± 14	501 ± 31	463 ± 18
	DIABETIC + LOC INS	8	282 ± 13	490 ± 38	465 ± 13
	DIABETIC + PHL	8	282 ± 13	492 ± 27	237 ± 45
	DIABETIC + PHL + LOC INS	8	259 ± 6	555 ± 19	155 ± 8
	DIABETIC + SYS INS	7	326 ± 8	448 ± 13	222 ± 13
8 weeks	CONTROL	8	475 ± 13	154 ± 19	140 ± 18
	DIABETIC	8	260 ± 9	478 ± 30	512 ± 29
	DIABETIC + LOC INS	7	314 ± 22	535 ± 34	468 ± 25
	DIABETIC + PHL	9	291 ± 21	536 ± 27	174 ± 18
	DIABETIC + PHL + LOC INS	10	271 ± 13	486 ± 33	220 ± 19
	DIABETIC + SYS INS	16	365 ± 10	526 ± 13	174 ± 29
12 weeks	CONTROL	8	564 ± 19	116 ± 5	105 ± 2
	DIABETIC	8	302 ± 17	453 ± 34	425 ± 25
	DIABETIC + LOC INS	9	305 ± 24	477 ± 27	418 ± 30
	DIABETIC + PHL	6	294 ± 20	461 ± 25	236 ± 22
	DIABETIC + PHL + LOC INS	8	320 ± 22	412 ± 28	178 ± 19
	DIABETIC + SYS INS	9	460 ± 9	456 ± 26	209 ± 29
Ins2^Akita mice
4 weeks	CONTROL	10	21.2 ± 0.3	N/A	180 ± 8
4 weeks	DIABETIC	10	21.6 ± 0.7	N/A	209 ± 32
8 weeks	CONTROL	9	29.4 ± 0.8	N/A	165 ± 12
8 weeks	DIABETIC	11	26.0 ± 0.5	N/A	450 ± 37
12 weeks	CONTROL	9	29.6 ± 0.9	N/A	177 ± 6
12 weeks	DIABETIC	10	25.8 ± 0.6	N/A	545 ± 16

Data are mean ± SEM. LOC INS, local insulin; N/A, not applicable; PHL, phloridzin; SYS INS, systemic insulin.