Table 2

MVPs associated with incident T2DM at P < 1.0E-07 in EPIC-Norfolk (N = 1,264)

CpG identifierChrPositionOR95% CIPFDRGene nameGene position
cg1969303111441529090.520.46–0.62.7E-211.3E-15TXNIP3′ UTR
cg0650016121425296561.651.45–1.896.4E-141.5E-08ABCG1Body
cg1447610111200575150.670.59–0.762.8E-103.9E-05PHGDHBody
cg1402017617702765801.631.4–1.93.3E-103.9E-05SLC9A3R13′ UTR
cg1102468217176708191.561.35–1.796.0E-105.7E-05SREBF1Body
cg0639716122380900051.511.32–1.734.5E-093.3E-04SYNGR1Body; TSS200
cg0057495811683641980.690.61–0.785.2E-093.3E-04CPT1A5′ UTR
cg0623542911671296901.491.3–1.75.5E-093.3E-04NDUFV1TSS1500
cg0577842417525245071.691.42–2.027.4E-093.9E-04AKAP15′ UTR
cg1137614711570177740.680.59–0.771.3E-086.0E-04SLC43A1Body
cg04816311710331761.511.31–1.751.7E-087.2E-04C7orf50Body
cg0271160819519798040.690.6–0.794.5E-081.5E-03SLC1A51st exon; 5′ UTR
cg0830968721342424660.680.6–0.784.5E-081.5E-03
cg13514042711587281.421.25–1.614.5E-081.5E-03
cg089940601062540320.650.55–0.765.2E-081.6E-03PFKFB3Body
cg016767957754242841.561.33–1.846.5E-081.8E-03PORBody
cg251303811273133081.491.29–1.736.7E-081.8E-03SLC9A1Body
cg1118322715892564111.491.29–1.727.0E-081.8E-03MAN2A2Body
  • Position: by HapMap build 37. OR: odds ratio per 1 SD in methylation intensity. Genes: gene names in which the CpG falls from 1,500 bp upstream of the transcriptional start site to the end of the 3′ UTR as in Illumina’s Infinium Human Methylation 450K BeadChip manifest file. Chr, chromosome; FDR, false discovery rate.