Table 1

Characteristics of the discovery and replication cohort from the NEO study

CharacteristicsInsulin30ΔInsulinIGIIRBMIadj
DiscoveryReplicationDiscoveryReplicationDiscoveryReplicationDiscoveryReplication
N3,5261,2393,5181,2333,4411,2023,5031,228
Age (years)56 (51, 61)56 (51, 61)56 (51, 61)56 (51, 61)56 (51, 61)56 (51, 61)56 (51, 61)56 (51, 61)
Women, N (%)1,757 (50.0)678 (54.7)1,753 (49.8)674 (54.7)1,701 (49.4)654 (54.4)1,743 (49.8)669 (54.5)
BMI (kg/m2)30.1 (28.3, 32.6)25.5 (23.2, 27.9)30.1 (28.3, 32.6)25.5 (23.3, 27.9)30.1 (28.3, 32.6)25.5 (23.2, 27.9)30.1 (28.3, 32.6)25.5 (23.2, 27.9)
Fasting serum measures
 Glucose (mmol/L)5.5 (5.2, 5.9)5.3 (5.0, 5.6)5.5 (5.2, 5.9)5.3 (5.0, 5.6)5.5 (5.2, 5.9)5.3 (5.0, 5.6)5.5 (5.2, 5.9)5.3 (5.0, 5.6)
 Insulin (mU/L)10.9 (7.5, 15.7)7.8 (5.2, 11.7)10.9 (7.5, 15.7)7.8 (5.2, 11.7)10.8 (7.4, 15.6)7.7 (5.2, 11.7)10.9 (7.5, 15.7)7.8 (5.2, 11.7)
 HbA1c (%)5.3 (5.2, 5.5)5.3 (5.1, 5.4)5.3 (5.2, 5.5)5.3 (5.1, 5.4)5.3 (5.2, 5.5)5.3 (5.1, 5.4)5.3 (5.2, 5.5)5.3 (5.1, 5.4)
Serum measures at 30 min
 Glucose (mmol/L)7.1 (6.2, 8.1)6.2 (5.3, 7.2)7.1 (6.2, 8.1)6.2 (5.3, 7.2)7.1 (6.2, 8.1)6.2 (5.3, 7.2)7.1 (6.2, 8.1)6.2 (5.3, 7.2)
 Insulin (mU/L)61.4 (42.8, 89.6)49.1 (34.9, 69.1)61.3 (42.7, 89.6)49.1 (34.9, 69.0)61.3 (42.8, 89.4)48.8 (34.6, 68.9)61.4 (42.8, 89.6)49.1 (34.8, 69.1)
  • Results are presented as median (interquartile range) unless otherwise indicated.