Table 3

Effect of type 2 diabetes–preventive strategies on 1-year change in CAD risk factors by study intervention

CRFPBO (n = 888)MET (n = 880)ILS (n = 890)PILS vs. PBOPMET vs. PBO
BMI, kg/m2−0.192 (−0.326, −0.057)−0.911 (−1.047, −0.774)−2.465 (−2.601, −2.330)<0.001<0.001
Waist circumference, cm−0.843 (−1.268, −0.417)−2.153 (−2.582, −1.725)−6.479 (−6.905, −6.053)<0.001<0.001
Fasting glucose, mmol/L#0.001 (−0.006, 0.007)−0.039 (−0.045, −0.032)−0.052 (−0.058, −0.045)<0.001<0.001
LDLc, mmol/L−0.060 (−0.097, −0.023)−0.116 (−0.154, −0.078)−0.161 (−0.199, −0.124)<0.0010.038
HDL, mmol/L−0.006 (−0.017, 0.005)0.021 (0.010, 0.032)0.038 (0.027, 0.049)<0.001<0.001
TG, mmol/L#−0.060 (−0.084, −0.036)−0.047 (−0.071, −0.023)−0.169 (−0.193, −0.145)<0.0010.452
SBP, mmHg−0.728 (−1.538, 0.081)−0.856 (−1.672, −0.040)−3.003 (−3.814, −2.192)<0.0010.828
DBP, mmHg−0.955 (−1.483, −0.428)−1.259 (−1.791, −0.728)−3.550 (−4.078, −3.022)<0.0010.427
CRP, mg/dL#−0.020 (−0.069, 0.029)−0.146 (−0.196, −0.097)−0.396 (−0.445, −0.347)<0.001<0.001
tPA, ng/mL−0.712 (−0.910, −0.515)−2.049 (−2.249, −1.849)−2.564 (−2.762, −2.367)<0.001<0.001
Fibrinogen, μmol/L0.084 (−0.039, 0.208)−0.063 (−0.188, 0.061)−0.298 (−0.421, −0.174)<0.0010.100
  • Values in this table represent adjusted mean (95% CI) change in CRF levels. P values from t tests comparing mean change in ILS or MET with PBO derived by general linear model adjusted for baseline risk factor, age at randomization, sex, and PCs ancestry markers.

  • # For nonnormally distributed variables, we calculated the natural log year 1 value minus natural log baseline value and show mean (95% CI) change in CRF levels.