Table 2

The median of the first FPIR and ΔFPIR over time according to different genotypes from 243 children with zero or one biochemical autoantibody at the time of the first IVGTT

ΔFPIR (mU/L/year)
SNP (n, % of total within the gene)Baseline FPIR (mU/L), median (95% CI)Age at the first IVGTT (years), median (IQR)Time between last and first IVGTT (years), median (range)Median (95% CI)nProgressors, n (%)
PTPN22 (237)77.6 (72.5, 87.8)6.1 (3.6, 8.1)2.3 (0.4–11.0)4.2 (2.6, 10.8)883 (1)
 AA (3, 1)74.3 (39.8, 281.2)6.1 (5.7, 7.5)NA (0)NA00
 AG (48, 20)73.0 (62.0, 91.9)4.6 (3.6, 7.5)2.1 (0.4–6.6)7.8 (2.9, 15.0)200
GG (186, 79)80.1 (74.3, 89.8)6.4 (3.6, 8.2)2.5 (0.6–11.0)3.8 (−0.3, 11.2)683 (2)
IFIH1 (128)75.7 (67.4, 88.8)5.1 (3.0, 7.8)2.3 (0.4–11.0)3.7 (1.5, 11.2)683 (2)
TT (45, 35)69.0 (57.2, 82.7)3.8 (2.9, 7.2)2.5 (0.6–7.4)−0.3 (−2.2, 12.7)193 (7)
 CT (60, 47)77.2 (63.0, 107.9)6.2 (3.5, 8.5)2.5 (0.4–11.0)8.0 (3.1, 15.1)330
 CC (23, 18)80.2 (66.0, 115.3)5.6 (2.5, 6.8)2.0 (0.8–7.4)1.5 (−12.3, 15.0)160
INS (239)77.6 (72.0, 87.1)6.0 (3.6, 8.1)2.3 (0.4–11.0)4.0 (2.6, 10.8)883 (1)
AA (151, 63)76.0 (68.4, 87.8)6.3 (3.6, 8.2)2.2 (0.4–7.7)3.4 (1.6, 10.8)643 (2)
AT (79, 33)82.7 (69.4, 102.1)5.3 (3.7, 7.5)2.9 (0.8–11.0)6.0 (−1.5, 13.0)230
 TT (9, 4)117.8 (53.1, 125.5)6.4 (3.6, 8.3)6.412.610
IKZF4 (125)75.2 (66.4, 87.1)5.3 (3.0, 7.8)2.3 (0.4–11.0)3.9 (1.6, 11.2)682 (2)
 CC (14, 11)69.8 (50.5, 119.8)3.9 (2.3, 7.6)2.1 (0.4–4.3)−1.0 (−9.0, 18.1)70
AC (51, 41)75.2 (61.4, 98.0)6.9 (3.6, 8.5)2.3 (0.6–7.4)6.2 (−0.3, 15.0)262 (4)
AA (60, 48)77.0 (66.0, 100.0)4.6 (3.0, 6.8)2.6 (0.8–11.0)3.8 (−1.0, 11.2)350
ERBB3 (236)77.4 (71.5, 86.8)6.1 (3.6, 8.1)2.3 (0.4–11.0)4.0 (2.6, 10.8)862 (1)
 AA (22, 9)92.4 (64.3, 140.9)6.3 (2.5, 8.9)2.4 (0.4–7.7)5.7 (−9.0, 30.0)60
CA (110, 47)77.6 (69.3, 89.1)6.8 (4.5, 8.1)2.2 (0.6–7.4)6.1 (2.6, 12.8)372 (2)
CC (104, 44)75.4 (67.4, 91.9)5.0 (3.1, 7.7)2.3 (0.8–11.0)3.7 (−0.5, 11.2)430
CTSH (241)77.6 (72.5, 87.8)6.1 (3.6, 8.1)2.3 (0.4–11.0)4.1 (2.6, 10.8)893 (12)
CC (89, 37)74.3 (65.3, 92.9)6.0 (4.1, 8.1)2.2 (0.6–6.6)4.5 (1.6, 11.2)341 (1)
CT (114, 47)80.1 (71.5, 93.1)6.2 (3.2, 8.1)2.5 (0.4–7.7)6.9 (−0.5, 16.9)422 (2)
 TT (38, 16)88.1 (67.4, 98.0)6.2 (4.4, 8.0)2.0 (0.8–11.0)2.7 (−12.3, 12.7)130
PTPN2 (238)77.6 (72.0, 87.1)6.1 (3.6, 8.1)2.3 (0.4–11.0)4.1 (2.6, 10.8)893 (1)
 CC (5, 2)88.8 (69.3, 131.5)6.3 (4.2, 8.8)3.1 (1.8–4.3)5.9 (−1.0, 12.8)20
GC (67, 28)74.3 (65.0, 86.8)6.1 (4.0, 8.3)1.9 (0.4–11.0)2.7 (−1.7, 14.9)262 (3)
GG (166, 70)80.2 (72.5, 93.1)6.1 (3.5, 8.0)2.5 (0.8–7.7)5.2 (2.7, 11.3)611 (1)
FUT2 (27)97.0 (64.3, 131.5)7.6 (2.3, 15.1)2.9 (0.6–5.9)8.9 (−2.5, 26.3)142 (7)
 AA (3, 11)82.7 (37.6, 131.5)4.5 (2.9, 9.1)3.5 (3.3–3.7)−1.5 (−2.5, −0.5)21 (33)
GA (19, 70)97.0 (60.0, 128.6)7.8 (3.0, 8.5)2.9 (0.6–5.9)12.7 (−5.0, 26.3)101 (5)
GG (5, 19)179.6 (55.8, 362.4)7.6 (4.9, 12.3)1.7 (1.4–2.0)−8.1 (−71.0, 54.9)20
Class I HLA alleles
A*24 (233)77.6 (72.5, 87.1)6.1 (3.7, 8.1)2.3 (0.4–11.0)4.2 (2.6, 10.8)842 (1)
  Present (48, 20)76.7 (65.3, 117.8)4.9 (2.9, 7.8)2.1 (1.1–11.0)11.2 (1.6, 26.0)161 (2)
  Absent (185, 76)78.2 (72.0, 87.1)6.3 (4.0, 8.2)2.3 (0.4–7.4)4.0 (2.3, 9.6)681 (1)
B*39 (232)77.4 (72.0, 86.8)6.1 (3.6, 8.1)2.3 (0.4–11.0)5.2 (2.8, 11.3)852 (1)
  Present (19, 8)98.0 (54.1, 144.6)5.0 (2.9, 8.3)2.2 (1.1–11.0)12.9 (−1.7, 187.8)71 (5)
   3901 (16, 7)80.5 (43.9, 130.0)4.8 (2.5, 8.1)3.0 (1.2–11.0)7.2 (−1.7, 46.2)61 (6)
   3906 (3, 1)148.0 (57.2, 186. 8)7.7 (3.5, 9.8)1.1187.810
  Absent (213, 92)77.2 (72.0, 85.7)6.1 (3.7, 8.1)2.4 (0.4–7.7)4.8 (2.8, 11.2)781 (0)
  • Major allele is marked in bold. NA, not available.

  • †Within each SNP, alleles associated with T1D risk are presented first.