Table 4

Association between CAD PRS and 1-year change in risk factors by study intervention

CRFAll study participants (n = 2,658)PBO (n = 888)MET (n = 880)ILS (n = 890)
β (95% CI)P*β (95% CI)P*β (95% CI)P*β (95% CI)P*
BMI, kg/m20.013 (−0.084, 0.109)0.7990.015 (−0.134, 0.164)0.8410.021 (−0.121, 0.163)0.7700.001 (−0.204, −0.201)0.994
Waist circumference, cm−0.027 (−0.330, 0.277)0.863−0.008 (−0.474, 0.457)0.972−0.212 (−0.724, 0.288)0.3980.168 (−0.433, 0.769)0.584
Fasting glucose, mmol/L#0.998 (0.994, 1.004)0.7280.999 (0.988, 1.005)0.4140.998 (0.991, 1.005)0.5261.002 (0.995, 1.011)0.502
Diabetes risk1.021 (0.919, 1.136)0.6960.952 (0.809, 1.120)0.5521.088 (0.904, 1.309)0.3711.068 (0.851, 1.341)0.571
LDLc, mmol/L0.010 (−0.017, 0.036)0.4810.012 (−0.036, 0.059)0.632−0.019 (−0.065, 0.028)0.4240.034 (−0.012, 0.080)0.152
HDLc, mmol/L−0.007 (−0.015, 0.001)0.075−0.009 (−0.022, 0.003)0.147−0.002 (−0.016, 0.012)0.822−0.013 (−0.028, 0.002)0.094
TG, mmol/L#1.016 (0.999, 1.033)0.0591.009 (0.998, 1.038)0.5621.011 (0.993, 1.040)0.4271.028 (0.999, 1.058)0.063
SBP, mmHg0.489 (−0.088, 1.067)0.0970.685 (−0.314, 1.683)0.179−0.288 (−1.267, 0.692)0.5650.951 (−0.073, 1.974)0.069
DBP, mmHg0.085 (−0.291, 0.462)0.6570.052 (−0.606, 0.711)0.876−0.150 (−0.797, 0.497)0.6490.256 (−0.398, 0.911)0.442
CRP, mg/dL#0.981 (0.947, 1.015)0.2720.967 (0.913, 1.024)0.2521.007 (0.946, 1.067)0.8110.971 (0.927, 1.033)0.354
tPA, ng/mL0.056 (−0.085, 0.197)0.4400.090 (−0.162, 0.024)0.4840.081 (−0.155, 0.318)0.5010.229 (−0.214, 0.259)0.850
Fibrinogen, μmol/L−0.019 (−0.106, 0.069)0.679−0.028 (−0.188, 0.131)0.7280.006 (−0.142, 0.154)0.935−0.037 (−0.188, 0.115)0.634
  • Each CRF represents a separate linear regression model on the association between 1-year change in CRF levels and the increment of 10 risk alleles in the PRS. Cox models were used to investigate the association between CAD PRS and diabetes incidence; estimates are reported as hazard ratios (95% CI).

  • # Regression coefficients for natural log–transformed CRFs are expressed as exp(β) ratio of 1-year change in CAD risk factors in the entire study population and according to intervention group.

  • * P value derived by general linear model adjusted for baseline risk factor, age at randomization, sex, and PCs ancestry markers.