Table 1

Characteristics of Gen3G mother-child pairs included in maternal insulin sensitivity EWAS of placenta

Mothers (N)430
 Age (years)28 (25; 31)
 Ethnicity, European descent430 (100.0)
 Gravidity, 1st pregnancy142 (33.0)
 Parity, 1st term pregnancy218 (50.7)
 Smoking in early pregnancy36 (8.4)
 BMI in early pregnancy (kg/m2)23.7 (21.6; 27.9)
 Waist circumference at 1st-trimester visit (cm)89.1 [82.0; 97.0]
 Blood pressure at 2nd-trimester visit (systolic/diastolic mmHg)107/67 (100/63; 112/72)
 OGTT (2nd trimester)
  Fasting glucose (mmol/L)4.2 (3.9; 4.4)
  1-h glucose (mmol/L)7.1 (6; 8.2)
  2-h glucose (mmol/L)5.7 (4.8; 6.6)
 Insulin sensitivity, Matsuda index (raw)7.72 (5.69; 10.67)
 Insulin sensitivity, Matsuda index (natural log transformed)2.04 (1.74; 2.37)
 GDM*37 (8.6)
Children
 Gestational age at birth (weeks)39.7 (38.9; 40.4)
 Female sex204 (47.4)
 Birth weight (kg)3.44 (3.17; 3.71)
 Large for gestational age, >90th percentile31 (7.2)
 Placental weight (g)542 (467; 642)
  • Data are median (IQR) or n (%) unless otherwise indicated.

  • * GDM was diagnosed according to International Association of the Diabetes and Pregnancy Study Groups.