Table 2

A1c Months and complications, in ascending order of A1c Months, in the EDC 1965–1980 diabetes diagnosis subcohort (n = 434)

ComplicationA1c Months at the time of incidence, mean (SD) and median complication (p25, p75)Hazard ratio per 100 A1c Months (95% CI)*P value
Microalbuminuria (n at risk = 234**, 99 events)844 (423)1.17 (1.11, 1.23)<0.0001
782 (573, 1,043)
Proliferative retinopathy (n at risk = 347**, 192 events)907 (383)1.14 (1.10, 1.18)<0.0001
866 (620, 1,187)
CDSP (n at risk = 325**, 127 events)963 (444)1.12 (1.07, 1.16)<0.0001
919 (629, 1,246)
CAD (n at risk = 413**, 98 events)1,068 (469)1.09 (1.04, 1.14)0.0004
986 (725, 1,398)
Overt nephropathy (n at risk = 314**, 61 events)1,139 (537)1.20 (1.14, 1.27)<0.0001
1,035 (744, 1,471)
ESRD (n at risk = 429**, 53 events)1,265 (495)1.18 (1.12, 1.25)<0.0001
1,274 (873, 1,618)
  • p25, 25th percentile; p75, 75th percentile.

  • * Estimated using time-varying Cox models.

  • ** Prevalent cases at baseline excluded from analysis.