Table 2

Repetitive intravenous administration of rhMG53 did not alter blood metabolites in rats

MaleFemale
Control1 mg/kg rhMG5310 mg/kg rhMG5340 mg/kg rhMG53Control1 mg/kg rhMG5310 mg/kg rhMG5340 mg/kg rhMG53
Blood urea nitrogen (mg/dL)14.7 ± 1.514.7 ± 1.516.7 ± 1.516.0 ± 1.021.7 ± 4.022.7 ± 1.220.0 ± 3.618.7 ± 2.1
Creatinine (mg/dL)0.190 ± 0.0000.197 ± 0.0210.220 ± 0.0360.267 ± 0.015#0.327 ± 0.0490.333 ± 0.0420.390 ± 0.0820.407 ± 0.064
Glucose (mg/dL)175 ± 4.4173.3 ± 21.9192.7 ± 16.3258.3 ± 33.1*176.7 ± 5.1187.7 ± 8.6184.0 ± 4.6206.3 ± 6.8*
AST (units/L)84.3 ± 12.981.3 ± 6.083.7 ± 10.074.7 ± 5.181.7 ± 20.274.7 ± 4.978.0 ± 5.677.7 ± 9.0
ALT (units/L)58.3 ± 6.759.0 ± 6.262.0 ± 15.555.7 ± 0.652.7 ± 4.046.7 ± 3.847.3 ± 4.547.0 ± 6
Alkaline phosphatase (units/L)368.3 ± 32.0352.7 ± 63.3394 ± 60.4325.0 ± 47.6199.0 ± 7.8180.0 ± 20.2171.3 ± 34.6187.3 ± 11.9
Cholesterol (mg/dL)89.3 ± 7.4100 ± 16.580.3 ± 7.092.0 ± 5.281.3 ± 18.980.3 ± 16.389.3 ± 22.992.3 ± 3.8
Triglyceride (mg/dL)149.0 ± 53.7103.0 ± 38.475.7 ± 34.299.0 ± 51.7126.7 ± 39.880.7 ± 16.040.3 ± 5.0*48.3 ± 9.3*
  • Data are means ± SD. Male and female rats were dosed intravenously with rhMG53 (0, 1, 10, and 40 mg/kg daily). n = 3/group. Blood metabolites at the end of the 14 days’ dosing were analyzed. ALT, alanine aminotransferase.

  • * P < 0.01.

  • # P < 0.05.