Table 1

Basic characteristics of nondiabetic and diabetic ApoE−/− mice treated with vehicle (SO) or dh404 at conclusion of 18-week study

ND+SO (n = 9)ND+dh-20 (n = 8)D+SO (n = 5)D+dh-3 (n = 7)D+dh-10 (n = 8)D+dh-20 (n = 9)
BW, g30.7 ± 0.931.1 ± 0.621.8 ± 0.4***27.5 ± 0.7**,###26.8 ± 0.6 ***,###23.0 ± 0.6***
Right kidney weight/BW, mg/g6.8 ± 0.26.4 ± 0.311.1 ± 0.4***8.4 ± 0.2*,##8.4 ± 0.7**,##9.0 ± 0.6**,##
Left kidney weight/BW, mg/g6.9 ± 0.16.9 ± 0.310.5 ± 0.3***8.4 ± 0.1#7.7 ± 0.5###9.3 ± 0.7***
Liver weight/BW, mg/g42.5 ± 1.543.9 ± 1.259.7 ± 1.3**52.1 ± 4.2*59.6 ± 2.0***58.8 ± 3.7***
Lung weight/BW, mg/g5.8 ± 0.25.9 ± 0.27.5 ± 0.4***6.6 ± 0.26.6 ± 0.27.3 ± 0.2***
Heart weight/BW, mg/g4.9 ± 0.15.6 ± 0.65.9 ± 0.25.5 ± 0.34.8 ± 0.16.0 ± 0.4
  • Data are presented as mean ± SEM.

  • BW, body weight; D, diabetic; dh-3, -10, and -20, dh404 at 3, 10, and 20 mg/kg/day; ND, nondiabetic.

  • *P < 0.05, **P < 0.01, ***P < 0.001 vs. ND+SO; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. D+SO.