Table 1

Anthropometric characteristics and indirect calorimetry data of T2D patients before and after 1 year of antidiabetic treatment initiation

Metformin monotherapyMetformin in combination with GLP-1 agonistsStatistical significance
Treatment variablePremetforminPostmetforminPre-exenatidePostexenatidePreliraglutidePostliraglutide
Sex (male/female)7/37/38/38/310/410/4ns
Age (years)65 ± 1167 ± 1466 ± 15ns
BMI (kg/m2)33.0 ± 6.631.4 ± 9.534.9 ± 2.632.1 ± 1.8*35.3 ± 2.232.0 ± 2.1**
Waist (cm)115 ± 13110 ± 19116 ± 10106 ± 15117 ± 11110 ± 16ns
Fat mass (%)39.0 ± 16.937.9 ± 9.439.5 ± 4.335.8 ± 3.7*39.2 ± 3.635.1 ± 3.3**
FFM (%)63.3 ± 17.067.1 ± 9.360.7 ± 4.264.3 ± 3.4*60.8 ± 3.164.9 ± 3.0**
REE (kJ/day)7,670 ± 1,0307,469 ± 1,2307,595 ± 8328,240 ± 9017,623 ± 1,0148,326 ± 1,107ns
REE (kJ/kg/day)74.9 ± 10.074.1 ± 11.775.7 ± 8.479.1 ± 8.776.0 ± 10.380.9 ± 11.2ns
REE (kJ/kg FFM/day)121.0 ± 16.7114.3 ± 18.8120.6 ± 5.1135.7 ± 6.0*122.4 ± 6.9143.6 ± 7.1**
RQ (vCO2/vO2)0.85 ± 0.020.84 ± 0.030.85 ± 0.040.85 ± 0.050.83 ± 0.060.84 ± 0.04ns
PAL1.47 ± 0.111.46 ± 0.081.45 ± 0.151.48 ± 0.121.46 ± 0.131.47 ± 0.16ns
  • Data are mean ± SEM unless otherwise indicated. ns, nonstatistically significant differences by repeated-measures ANOVA, MANOVA, and two-tailed paired Student t test between pre- and postvalues within a same treatment group.

  • *P < 0.05 by repeated-measures ANOVA and compared with baseline (pre) values within the same treatment group by two-tailed paired Student t test.