Table 1

Body weight and serum biochemical profiles of Uox-KO and WT mice after 20 weeks on an HFD or normal chow diet

CharacteristicWT (n = 8)KO (n = 8)
ChowHFDChowHFD
SU (mg/dL)2.51 ± 0.242.66 ± 0.288.58 ± 0.40###8.49 ± 0.55###
TC (mmol/L)2.88 ± 0.084.30 ± 0.15**2.74 ± 0.104.05 ± 0.34**
TG (mmol/L)1.44 ± 0.051.85 ± 0.20**1.13 ± 0.071.78 ± 0.30**
LDL cholesterol (mmol/L)0.94 ± 0.051.26 ± 0.19*1.01 ± 0.081.35 ± 0.20*
HDL cholesterol (mmol/L)0.92 ± 0.040.81 ± 0.10*0.88 ± 0.090.73 ± 0.25*
Body weight (g)32.7 ± 0.6635.9 ± 0.58***31.5 ± 0.7434.1 ± 0.81***##
Plasma insulin (ng/mL)0.53 ± 0.040.58 ± 0.040.80 ± 0.05#0.32 ± 0.03***##
  • Data are expressed as mean ± SEM.

  • * P < 0.05,

  • ** P < 0.01,

  • *** P < 0.001, chow diet vs. HFD;

  • # P < 0.05,

  • ## P < 0.01,

  • ### P < 0.001, WT vs. KO.