Table 2

Direct comparisons of allelic sequences within mixture 1 and 2 results in identification of 12 and 25 AAs that differentiate between risk and protective alleles in, respectively, DQ8/9 and DQ2 mixtures of haplotypes

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  • Estimated haplotype frequencies (%) among control subjects, those among patients, estimated ORs, z scores, and P values are listed. Risk and protective haplotypes are highlighted green and red, respectively, at the significance level of 5%. Neutrally associated haplotypes with more than three subjects are in black font, while neutrally associated haplotypes with fewer than three subjects are colored gray. The AA β26 has a variant G only on the rare DQ haplotype and is thus excluded from further analysis. Similarly, the AA α(−13) has a variant T-associated haplotype and is also excluded.