Table 1

Autoantigens and derivative peptide epitopes tested in T-cell assays

Parent antigenRegionSequenceRelevant T-cell studiesDesignation in analyses
Insulin (A + B chains)A1–21GIVEQCCTSICSLYQLENYCNKN/AIns (1)
B1–20FVNQHLCGSHLVEALYLVCGKN/AIns (2)
B6–25LCGSHLVEALYLVCGERGFFKN/AIns (3)
B11–30LVEALYLVCGERGFFYTPKTKN/AIns (4)
ProinsulinC13–32GGGPGAGSLQPLALEGSLQK 6PI (5)
C19-A3GSLQPLALEGSLQKRGIV 4,6,13PI (6)
C22-A5QPLALEGSLQKRGIVEQ 6PI (7)
IA-2709–736LAKEWQALCAYQAEPNTCATAQGEGNIK 4,6,13IA-2 (8)
752–775KLKVESSPSRSDYINASPIIEHDP 4,6,13IA-2 (9)
853–872SFYLKNVQTQETRTLTQFHF 4,6,13IA-2 (10)
GAD65335–352TAGTTVYGAFDPLLAVAD 4,13GAD (11)
555–567NFIRMVISNPAAT 4GAD (12)
  • Ins, insulin; PI, proinsulin.